4-(p-硝基苯氧基)丁酸甲酯合成路线 （共 4 条）
反应条件
sodium hydroxide in tetrahydrofuran; water 2 h; Reflux;
参考文献
Zhang, Xuan; Bao, Bin; Yu, Xiuhua; Tong, Linjiang; Luo, Yu; Huang, Qingqing; Su, Mingbo; Sheng, Li; Li, Jia; Zhu, Hong; Yang, Bo; Zhang, Xiongwen; Chen, Yi; Lu, Wei
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 6981 - 6995
反应条件
1: H2 / Pd/C / ethyl acetate 2: 41 percent / AcOH / tetrahydrofuran / 48 h / 110 - 120 °C 3: POCl3 / benzene / 1 h / Heating 4: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min 5: EtOCOCl, Et3N / acetone / 0.25 h / 0 °C 6: aq. NaN3 / acetone / 0.5 h / 0 °C 7: benzene / 1 h / Heating 8: 8 N HCl / 0.17 h / Heating 9: methanol / 24 h / 20 °C View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=90°C; 16 h;
参考文献
Zhang, Xuan; Bao, Bin; Yu, Xiuhua; Tong, Linjiang; Luo, Yu; Huang, Qingqing; Su, Mingbo; Sheng, Li; Li, Jia; Zhu, Hong; Yang, Bo; Zhang, Xiongwen; Chen, Yi; Lu, Wei
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 6981 - 6995
反应条件
1: H2 / Pd/C / ethyl acetate
2: 41 percent / AcOH / tetrahydrofuran / 48 h / 110 - 120 °C
3: POCl3 / benzene / 1 h / Heating
4: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min
View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
