2,7-二溴-9,9-二甲基芴合成路线 （共 14 条）
反应条件
potassium tert-butylate in dimethyl sulfoxide T=5°C;
参考文献
EP1860097 A1, ;
Page/Page column 21; 22 ;
反应条件
1: 2,7-dibromo-9H-fluorene With potassium tert-butylate in dimethyl sulfoxide T=5°C; 2: methyl iodide in dimethyl sulfoxide T=5°C;
参考文献
WO2006/100896 A1, ;
Page/Page column 31-33 ;
参考文献
Journal of the Chemical Society [Section] B: Physical Organic, , p. 975 - 979
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium acetate in 1,4-dioxane T=80°C; Miyaura Borylation Reaction; 16 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 5 p. 2033 - 2046
反应条件
n-butyllithium in diethyl ether T=-78 - 20°C; 14 h; Inert atmosphere;
参考文献
Advanced Functional Materials, , vol. 23, # 10 p. 1323 - 1330
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-70 - -65°C; 6 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-70 - 20°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water pH=3;
参考文献
IDEMITSU KOSAN CO., LTD.
Patent: EP1860097 A1, 2007 ;
Location in patent: Page/Page column 21; 22 ;
反应条件
1: 2,2’-dibromo-9,9’-dimethyl-fluorene With n-butyllithium in tetrahydrofuran; hexane T=-70 - -65°C; 6 h; Inert atmosphere; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-70 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane; water pH=3;
参考文献
Idemitsu Kosan Co., Ltd.
Patent: US8058450 B2, 2011 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: 2,2’-dibromo-9,9’-dimethyl-fluorene With n-butyllithium in diethyl ether; hexane T=-78 - 20°C; 2: tri-isopropoxy-borane in diethyl ether; hexane T=-78 - 20°C; 3: water in diethyl ether; hexane
参考文献
Samsung Mobile Display Co., Ltd.
Patent: EP2149555 A1, 2010 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 2,2’-dibromo-9,9’-dimethyl-fluorene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran; hexane 12 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water
参考文献
ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; LEE, Soo Yong; CHO, Young Jun; KWON, Hyuck Joo; KIM, Sung Min; KIM, Bong Ok
Patent: WO2011/136520 A1, 2011 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
1: boric acid trimethyl ester; 2,2’-dibromo-9,9’-dimethyl-fluorene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: hydrogenchloride in tetrahydrofuran; hexane
参考文献
ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD; LEE, Soo Young; CHO, Young Jun; KIM, Bong Ok; KIM, Sung Min
Patent: WO2012/15265 A1, 2012 ;
Location in patent: Page/Page column 19-20 ;
