5-溴-2，4-二氟苯甲酸合成路线 （共 5 条）
反应条件
potassium hydroxide in ethanol; water 2 h; Heating;
参考文献
Schlosser, Manfred; Heiss, Christophe
European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624
反应条件
1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C 2: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h 3: 70 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 4: 95 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Schlosser, Manfred; Heiss, Christophe
European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624
反应条件
1: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h 2: 70 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 3: 95 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Schlosser, Manfred; Heiss, Christophe
European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624
反应条件
1: 70 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 2: 95 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Schlosser, Manfred; Heiss, Christophe
European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624
反应条件
iron tribromide; bromine
参考文献
Issa, W.; Tochon-Danguy, H. J.; Lambert, J.; Sachinidis, J.; Ackerman, U.; Lee, F. T.; Scott, A. M.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S393 - S395
