5-甲氧基-异苯并呋喃-1,3-二酮合成路线 （共 25 条）
反应条件
acetic anhydride in tetrahydrofuran 4 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 277-278 ;
WO 2008/044045 A1
反应条件
carbon monoxide; tetracarbonylnickel(0); benzene T=325°C; P=73550.8 Torr;
参考文献
Prichard
Journal of the American Chemical Society, 1956 , vol. 78, p. 6137
反应条件
potassium permanganate; hydroxide
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
反应条件
1: 210 °C 2: 57 percent / diethyl ether View Scheme
参考文献
De Nanteuil, Florian; Serrano, Eloisa; Perrotta, Daniele; Waser, Jerome
Journal of the American Chemical Society, 2014 , vol. 136, # 17 p. 6239 - 6242
参考文献
Hinde, Nicholas J.; Hall, C. Dennis
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 5 p. 1249 - 1256
反应条件
1.1: potassium carbonate / acetone / 0.33 h / 50 °C / |Inert atmosphere 1.2: |Inert atmosphere; |Reflux 2.1: sodium hydroxide / acetone / 6 h / 20 °C / |Inert atmosphere 3.1: acetic anhydride / 21 h / |Inert atmosphere; |Reflux View Scheme
参考文献
De Nanteuil, Florian; Serrano, Eloisa; Perrotta, Daniele; Waser, Jerome
Journal of the American Chemical Society, 2014 , vol. 136, # 17 p. 6239 - 6242
反应条件
1: sodium hydroxide / acetone / 6 h / 20 °C / |Inert atmosphere 2: acetic anhydride / 21 h / |Inert atmosphere; |Reflux View Scheme
参考文献
De Nanteuil, Florian; Serrano, Eloisa; Perrotta, Daniele; Waser, Jerome
Journal of the American Chemical Society, 2014 , vol. 136, # 17 p. 6239 - 6242
反应条件
1: 39 percent / chloral 2: 88 percent / KMnO4, OH(1-) View Scheme
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
反应条件
1: KMnO4; alkali 2: Erhitzen auf den Schmelzpunkt View Scheme
参考文献
Jacobsen
Chemische Berichte, 1883 , vol. 16, p. 1964
Full Text Show Details
Baudisch; Perkin
Journal of the Chemical Society, 1909 , vol. 95, p. 1883
反应条件
1: H2SO4 (65 percent SO3) / 3 h / 200 °C 2: NaOH / 2.5 h / 175 °C 3: 53 percent / K2CO3 / 2 h / 90 °C 4: 0.25 h / 170 °C View Scheme
参考文献
Hennige, Hans; Kreher, Richard P.; Konrad, Michael; Jelitto, Frank
Chemische Berichte, 1988 , vol. 121, p. 243 - 252
