(4-羟基-苯基)-磷酸二乙酯合成路线 （共 8 条）
反应条件
trimethylsilyl bromide in acetonitrile 24 h; Heating / reflux;
参考文献
THE UNIVERSITY OF WESTERN AUSTRALIA; THE CURATORS OF THE UNIVERSITY OF MISSOURI
Patent: WO2008/148168 A1, 2008 ;
Location in patent: Page/Page column 55-56 ;
反应条件
1: With potassium hydroxide; water in tetrahydrofuran; methanol
T=20°C; 2 h;
2: With hydrogenchloride in dichloromethane; water
参考文献
THE UNIVERSITY OF WESTERN AUSTRALIA; THE CURATORS OF THE UNIVERSITY OF MISSOURI
Patent: WO2008/148168 A1, 2008 ;
Location in patent: Page/Page column 54-55 ;
反应条件
N-ethyl-N,N-diisopropylamine; palladium diacetate; triphenylphosphine in ethanol
T=76°C; 16 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/154563 A1, 2008 ;
Location in patent: Page/Page column 83-84 ;
WO 2008/154563 A1
反应条件
niobium bromide in 1,3,5-trimethyl-benzene
T=160 - 180°C; Arbuzov reaction; 2 h;
参考文献
Lejeune, Nicolas; Dez, Isabelle; Jaffres, Paul-Alain; Lohier, Jean-Fancois; Madec, Pierre-Jean; Santos, Jana Sopkova-De Oliveira
European Journal of Inorganic Chemistry, 2008 , # 1 p. 138 - 143
反应条件
palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran
T=25°C; Hirao reaction; 16 h; Inert atmosphereDarkness;
参考文献
Kohler, Mark C.; Sokol, Joseph G.; Stockland Jr., Robert A.
Tetrahedron Letters, 2009 , vol. 50, # 4 p. 457 - 459
反应条件
hydrogenchloride; EtO-NO
参考文献
Freedman; Jaffe
Journal of the American Chemical Society, 1955 , vol. 77, p. 920
反应条件
1: 90 percent / HSiEt3, NEt3 / PdCl2(PPh3)2 / toluene / 22 h / 90 °C
2: 1.) EtMgBr, 2.) hydrochloric acid / 1.) THF, reflux, 6 h, 2.) THF
View Scheme
参考文献
Jaffres, Paul-Alain; Bar, Nathalie; Villemin, Didier
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 13 p. 2083 - 2089
反应条件
water; sodium hydroxide
T=80°C;
参考文献
Seo, Jungmin; Park, Youngchul; Jeon, Incheol; Ryu, Taekyu; Park, Sangjune; Lee, Phil Ho
Organic Letters, 2013 , vol. 15, # 13 p. 3358 - 3361
