chlorine; acetic acid

ammonia

1: aq. NaOH / 10 h / 10 °C / pH 10 - 10.5 2: SOCl2 / CH2Cl2 / 2 h / Heating 3: NaHCO3; Na2CO3 / CH2Cl2; H2O / 0 - 5 °C 4: K2CO3 / acetonitrile / 3 h / 35 °C 5: K2CO3 / dimethylformamide / 3 h / 20 °C View Scheme

triethylamine in dichloromethane T=20°C; 2 h;