3,4-二氢-3-羟基-4-氧-1,2,3-苯并三嗪合成路线 （共 15 条）
反应条件
hydrogenchloride; sodium nitrite in water T=0 - 20°C; 1 - 2 h;
参考文献
FRUTAROM LTD.
Patent: WO2005/7634 A1, 2005 ;
Location in patent: Page 39 ;
反应条件
1: benzene / 12 h / Ambient temperature 2: 12 N HCl, NaNO2 / H2O / 0.5 h / 4 °C View Scheme
参考文献
Jakobsen, Mogens Havsteen; Buchardt, Ole; Holm, Arne; Meldal, Morten
Synthesis, 1990 , # 11 p. 1008 - 1010
反应条件
1: NH2OH; NaOH 2: HCl; NaNO2 View Scheme
参考文献
Vaughan, Keith; Wilman, Derry E. V.; Wheelhouse, Richard T.; Stevens, Malcolm F. G.
Magnetic Resonance in Chemistry, 2002 , vol. 40, # 4 p. 300 - 302
反应条件
1: 87 percent / diethyl ether 2: 62 percent / CF3COOH, 60percent aq. H2O2 / 1.) 20 deg C, 18 h, 2.) 60 deg C, 4 h 3: H2 / 5percent Pd/C / ethanol / 0.02 h / 760 Torr View Scheme
参考文献
Boulton, A. J.; Devi, Purabi; Henderson, Neil; Jarrar, Adil A.; Kiss, Miklos
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 543 - 546
反应条件
dicyclohexyl-carbodiimide in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Meinjohanns, Ernst; Meldal, Morten; Jensen, Teis; Werdelin, Ole; Galli-Stampino, Luisa; Mouritsen, Soren; Bock, Klaus
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 871 - 884
反应条件
dicyclohexyl-carbodiimide 1.) THF, -15 deg C, 5 min, 2.) THF, a) -10 deg C, 30 min, b) 0 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Qasmi, Driss; De Rosny, Eve; Rene, Loic; Badet, Bernard; Vergely, Isabelle; Boggetto, Nicole; Reboud-Ravaux, Michele
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 707 - 714
反应条件
triethylamine in dichloromethane 3 h;
参考文献
Li; Jiang; Ye; Fan; Romoff; Goodman
Organic letters, 1999 , vol. 1, # 1 p. 91 - 93
反应条件
triethylamine in dichloromethane; benzene 4 h;
参考文献
Fan, Chong-Xu; Hao, Xiao-Lin; Ye, Yun-Hua
Synthetic Communications, 1996 , vol. 26, # 7 p. 1455 - 1460
反应条件
NMM; trifluoroacetic acid in water; acetic acid; N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US6174858 B1, 2001 ;
反应条件
NMM; trifluoroacetic acid in Waters C18; water; acetic acid; N,N-dimethyl-formamide
参考文献
DeFeo-Jones, Deborah; Heimbrook, David C.; Jones, Raymond E.
Patent: US2002/41880 A1, 2002 ;
