2-羟基-3-硝基苯乙酮合成路线 （共 15 条）
反应条件
nitric acid; acetic acid 1.) RT, 40 min, 2.) from 45 to 50 deg C, 16 h;
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
sulfuric acid; sodium nitrite in ethanol; water 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h;
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
nitric acid in acetic acid
参考文献
Huang; Fu-Chich; Campbell; Henry F.; Learn; Keith S.
Patent: US5082849 A1, 1992 ;
US 5082849 A
反应条件
nitric acid in acetic acid
参考文献
Allan; Loudon
Journal of the Chemical Society, 1949 , p. 821,824
Full Text Show Details
Joshi; Singh
Journal of the American Chemical Society, 1954 , vol. 76, p. 4993
反应条件
N,N-dimethyl-formamide; zinc T=64°C; Fries rearrangement; 13 h; microwave irradiation;
参考文献
Paul, Satya; Gupta, Monika
Synthesis, 2004 , # 11 p. 1789 - 1792
反应条件
1: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr 2: tetrahydrofuran / 0.33 h / 60 °C 3: 71 percent / nitric acid, glacial acetic acid / 2 h / Ambient temperature 4: 96 percent / methanol; H2O / 1 h / 85 °C 5: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: 71 percent / nitric acid, glacial acetic acid / 2 h / Ambient temperature 2: 96 percent / methanol; H2O / 1 h / 85 °C 3: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: tetrahydrofuran / 0.33 h / 60 °C 2: 71 percent / nitric acid, glacial acetic acid / 2 h / Ambient temperature 3: 96 percent / methanol; H2O / 1 h / 85 °C 4: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: 96 percent / methanol; H2O / 1 h / 85 °C 2: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
nitric acid; acetic acid
参考文献
Wittig
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 179
