反式-2,5-二甲基哌嗪合成路线

106-95-63-溴丙烯+2815-34-1反式-2,5-二甲基哌嗪→155836-78-5(2R,5S)-1-烯丙基-2,5-二甲基哌嗪+155836-79-6(+)-(2S,5R)-1-烯丙基-2,5-二甲基哌嗪

参考文献

Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2125 - 2128

2815-34-1反式-2,5-二甲基哌嗪→155836-78-5(2R,5S)-1-烯丙基-2,5-二甲基哌嗪

参考文献

Janetka, James W.; Furness, M. Scott; Zhang, Xiaoyan; Coop, Andrew; Folk, John E.; Mattson, Mariena V.; Jacobson, Arthur E.; Rice, Kenner C.
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 3976 - 3980

106-95-63-溴丙烯+2815-34-1反式-2,5-二甲基哌嗪→155836-78-5(2R,5S)-1-烯丙基-2,5-二甲基哌嗪+155836-79-6(+)-(2S,5R)-1-烯丙基-2,5-二甲基哌嗪

参考文献

Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2125 - 2128

2815-34-1反式-2,5-二甲基哌嗪→178803-51-54-[(S)-[(2S,5R)-2,5-二甲基-4-(2-丙烯-1-基)-1-哌嗪基]苯基甲基]-N,N-二乙基苯甲酰胺

参考文献

Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704

100-39-0溴化苄+2815-34-1反式-2,5-二甲基哌嗪→260254-80-6(2S,5R)-1-苄基-2,5-二甲基哌嗪+216532-43-3(2R,5S)-1-苄基-2,5-二甲基哌嗪

参考文献

PFIZER INC.
Patent: WO2008/96260 A1, 2008 ;
Location in patent: Page/Page column 41 ;
WO 2008/096260 A1

2815-34-1反式-2,5-二甲基哌嗪→216532-43-3(2R,5S)-1-苄基-2,5-二甲基哌嗪

参考文献

Aicher, Thomas D.; Anderson, Robert C.; Gao, Jiaping; Shetty, Suraj S.; Coppola, Gary M.; Stanton, James L.; Knorr, Douglas C.; Sperbeck, Donald M.; Brand, Leonard J.; Vinluan, Christine C.; Kaplan, Emma L.; Dragland, Carol J.; Tomaselli, Hollis C.; Islam, Amin; Lozito, Robert J.; Liu, Xilin; Maniara, Wieslawa M.; Fillers, William S.; Dominick Delgrande; Walter, Eric; Mann, William R.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 236 - 249

100-44-7苄基氯+2815-34-1反式-2,5-二甲基哌嗪→216532-43-3(2R,5S)-1-苄基-2,5-二甲基哌嗪

参考文献

Aicher, Thomas D.; Anderson, Robert C.; Bebernitz, Gregory R.; Coppola, Gary M.; Jewell, Charles F.; Knorr, Douglas C.; Liu, Charles; Sperbeck, Donald M.; Brand, Leonard J.; Strohschein, Robert J.; Gao, Jiaping; Vinluan, Christine C.; Shetty, Suraj S.; Dragland, Carol; Kaplan, Emma L.; DelGrande, Dominick; Islam, Amin; Liu, Xilin; Lozito, Robert J.; Maniara, Wieslawa M.; Walter, R. Erik; Mann, William R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2741 - 2746

352-11-44-氟氯苄+2815-34-1反式-2,5-二甲基哌嗪→364066-92-2(2S,5r)-1-(4-氟苄基)-2,5-二甲基哌嗪

参考文献

Belecki, Katherine; Berliner, Martin; Bibart, Richard Todd; Meltz, Cliff; Ng, Karl; Phillips, James; Ripin, David H. Brown; Vetelino, Michael
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 754 - 761

2815-34-1反式-2,5-二甲基哌嗪→156727-74-1(+)-4-[(ΑR)-Α-((2S,5R)-4-烯丙基-2,5-二甲基-1-哌嗪基)-3-甲氧基苄基]-N,N-二乙基苯酰胺

参考文献

Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2125 - 2128