5-胸腺嘧啶基-5,6-二氢胸腺嘧啶合成路线 （共 3 条）
反应条件
trifluoroacetic acid T=60°C; 2 h;
参考文献
Nicewonger, Robb; Begley, Tadhg P.
Tetrahedron Letters, 1997 , vol. 38, # 6 p. 935 - 936
反应条件
1: 88 percent / NaH / dimethylformamide / 18 h / Ambient temperature 2: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h 3: PBr3 / tetrahydrofuran / 0.17 h / Ambient temperature 4: Bu3SnH, AlBN / toluene / 0.5 h / Heating 5: 40 percent / CAN / acetonitrile; H2O / 2 h / Ambient temperature 6: 70 percent / TFA / 2 h / 60 °C View Scheme
参考文献
Nicewonger, Robb; Begley, Tadhg P.
Tetrahedron Letters, 1997 , vol. 38, # 6 p. 935 - 936
反应条件
1: 63 percent / NaH / dimethylformamide / 8 h / Ambient temperature 2: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h 3: PBr3 / tetrahydrofuran / 0.17 h / Ambient temperature 4: Bu3SnH, AlBN / toluene / 0.5 h / Heating 5: 40 percent / CAN / acetonitrile; H2O / 2 h / Ambient temperature 6: 70 percent / TFA / 2 h / 60 °C View Scheme
参考文献
Nicewonger, Robb; Begley, Tadhg P.
Tetrahedron Letters, 1997 , vol. 38, # 6 p. 935 - 936
