(Z)-8-十二烯基乙酸酯合成路线 （共 53 条）
反应条件
1: 80.7 percent Turnov. / Ba(OH)2*8H2O / methanol; benzene / 20 h / Ambient temperature 2: 45 percent / lead tetraacetate, pyridine, Cu(OAc)2 / benzene / 3 h / Heating 3: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h 4: 86.2 percent / conc.H2SO4 / 4 h / Heating 5: 96 percent / LAH / diethyl ether / 2 h / Ambient temperature 6: 90.6 percent / PPTS / CH2Cl2 / 4 h / Ambient temperature 7: 1) n-BuLi, 2) HMPT / 1) THF, hexane, 10 deg C, 2) <25 deg C, 0.5 h 8: 83 percent / AcOH 9: 97 percent / H2, quinoline / 5percent Pd/BaSO4 / methanol View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
1: 1) Br2, 2) aq.KOH / 1) CCl4, r.t., 2) 135-145 deg C, 4 h 2: 86.2 percent / conc.H2SO4 / 4 h / Heating 3: 96 percent / LAH / diethyl ether / 2 h / Ambient temperature 4: 90.6 percent / PPTS / CH2Cl2 / 4 h / Ambient temperature 5: 1) n-BuLi, 2) HMPT / 1) THF, hexane, 10 deg C, 2) <25 deg C, 0.5 h 6: 83 percent / AcOH 7: 97 percent / H2, quinoline / 5percent Pd/BaSO4 / methanol View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
1: 83 percent / AcOH 2: 97 percent / H2, quinoline / 5percent Pd/BaSO4 / methanol View Scheme
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
n-butyllithium in tetrahydrofuran; hexane T=18°C; 2 h; Further stages. Title compound not separated from byproducts.;
参考文献
Huang; Li; Lu; Aisa
Chemistry of Natural Compounds, 2006 , vol. 42, # 6 p. 727 - 729
反应条件
1: 90 percent / NaI / dimethylformamide / 42 h / 60 °C 3: sodium hydroxide / dioxane / 17 h / Ambient temperature; further solvents were also used 4: Adogen, sodium dithionite, NaHCO3 / cyclohexane; H2O / 2 h / Heating 5: pyridine / 4 h / Ambient temperature View Scheme
参考文献
Julia, Marc; Stacino, Jean-Pierre
Tetrahedron, 1986 , vol. 42, # 9 p. 2469 - 2474
反应条件
2: sodium hydroxide / dioxane / 17 h / Ambient temperature; further solvents were also used 3: Adogen, sodium dithionite, NaHCO3 / cyclohexane; H2O / 2 h / Heating 4: pyridine / 4 h / Ambient temperature View Scheme
参考文献
Julia, Marc; Stacino, Jean-Pierre
Tetrahedron, 1986 , vol. 42, # 9 p. 2469 - 2474
反应条件
1: Adogen, sodium dithionite, NaHCO3 / cyclohexane; H2O / 2 h / Heating 2: pyridine / 4 h / Ambient temperature View Scheme
参考文献
Julia, Marc; Stacino, Jean-Pierre
Tetrahedron, 1986 , vol. 42, # 9 p. 2469 - 2474
反应条件
1: sodium hydroxide / dioxane / 17 h / Ambient temperature; further solvents were also used 2: Adogen, sodium dithionite, NaHCO3 / cyclohexane; H2O / 2 h / Heating 3: pyridine / 4 h / Ambient temperature View Scheme
参考文献
Julia, Marc; Stacino, Jean-Pierre
Tetrahedron, 1986 , vol. 42, # 9 p. 2469 - 2474
反应条件
1: 1.) BuSnCl3 / 1.) CHCl3, 0 deg C, 2 min, 2.) CHCl3, 0 deg C, 30 min 2: DMPA / CH2Cl2 3: 58 percent / NaBH4 / dimethylsulfoxide / 80 °C View Scheme
参考文献
Miyake, Hideyoshi; Yamamura, Kimiaki
Chemistry Letters, 1994 , # 5 p. 897 - 900
反应条件
1: 1.) BuSnCl3 / 1.) CHCl3, 0 deg C, 2 min, 2.) CHCl3, 0 deg C, 30 min 2: DMPA / CH2Cl2 3: 58 percent / NaBH4 / dimethylsulfoxide / 80 °C View Scheme
参考文献
Miyake, Hideyoshi; Yamamura, Kimiaki
Chemistry Letters, 1994 , # 5 p. 897 - 900
