1-环状己烯三氟甲烷磺酸合成路线 （共 56 条）
反应条件
1.1: Zn; TMSCl / dimethylformamide / 0.33 h / 0 °C
1.2: 41 percent / Pd(PPh3)2Cl2 / dimethylformamide / 16 h / 50 °C
2.1: 96 percent / H2 / Pd/C / methanol / 24 h
View Scheme
参考文献
Carrillo-Marquez, Tomas; Caggiano, Lorenzo; Jackson, Richard F. W.; Grabowska, Urszula; Rae, Alastair; Tozer, Matthew J.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4117 - 4123
反应条件
in ammonia
T=-33°C; 32 h;
参考文献
Creary, Xavier; Benage, Brigitte; Hilton, Kathryn
Journal of Organic Chemistry, 1983 , vol. 48, # 17 p. 2887 - 2891
反应条件
1: benzyl bromide With zinc in tetrahydrofuran
T=0°C; 2 h;
2: cyclohex-1-en-1-yl trifluoromethanesulfonate With 1,1'-bis-(diphenylphosphino)ferrocene; tetra-(n-butyl)ammonium iodide; bis(dibenzylideneacetone) palladium in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=60°C; 1 h; Further stages.;
参考文献
Piber, Michael; Jensen, Anne Eeg; Rottlaender, Mario; Knochel, Paul
Organic Letters, 1999 , vol. 1, # 9 p. 1323 - 1326
反应条件
tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; triethylamine in toluene
T=110°C; 16 h; Inert atmosphere;
参考文献
Vinogradova, Ekaterina V.; Fors, Brett P.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 27 p. 11132 - 11135
反应条件
1: Et3N, dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 4 h / 75 - 77 °C / further reagents and solvents
2: 86 percent / aq. NaOH / methanol / 2 h / 65 - 67 °C
View Scheme
参考文献
Lai, Gaifa; McAllister, Timothy
Synthetic Communications, 1999 , vol. 29, # 3 p. 409 - 413
反应条件
piperidine; tetrakis(triphenylphosphine) palladium(0)
T=25°C; 0.0833333 h;
参考文献
Alami; Ferri; Linstrumelle
Tetrahedron Letters, 1993 , vol. 34, # 40 p. 6403 - 6406
