4-羟基-7-甲氧基喹啉-3-甲酸合成路线 （共 7 条）
反应条件
sodium hydroxide in water 1 h; Reflux;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1.1: toluene / 1 h / Heating 1.2: 14 percent / diphenyl ether / 12 h / 230 °C 2.1: aq. sodium hydroxide / 1 h / Heating View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: diphenyl ether / 1 h / Heating 2: POCl3 / 1.17 h / 100 - 110 °C View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: diphenylether / 1 h / |Reflux 2: trichlorophosphate / 0.33 h / 140 °C 3: ammonium hydroxide; zinc(II) chloride / 1.5 h / 160 - 180 °C / 15376.5 Torr / |Microwave irradiation View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
in diphenylether 1 h; Reflux;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: diphenyl ether / 1 h / Heating
2: POCl3 / 1.17 h / 100 - 110 °C
3: a) 80-100 deg C, 1 h, b) 135-150 deg C, 8 h
View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
