3,5-二羟基-4-甲基苯甲酸合成路线 （共 22 条）
反应条件
sodium hydroxide; nickel T=25°C; 12 h;
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Patent: EP2199295 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
bromine in acetic acid 1.) room temperature, 2.) reflux, 46 h;
参考文献
Carey; Giuliano
Journal of Organic Chemistry, 1981 , vol. 46, # 7 p. 1366 - 1371
反应条件
1: 97 percent / Br2 / CHCl3 / 5 h / 25 °C 2: 98 percent / gl. AcOH / H2O; ethanol / 24 h / 25 °C 3: 70 percent / 3N NaOH, Raney nickel / 12 h / 25 °C View Scheme
参考文献
Borchardt, Ronald T.; Sinhababu, Achintya K.
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 5021 - 5022
反应条件
1: 98 percent / gl. AcOH / H2O; ethanol / 24 h / 25 °C 2: 70 percent / 3N NaOH, Raney nickel / 12 h / 25 °C View Scheme
参考文献
Borchardt, Ronald T.; Sinhababu, Achintya K.
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 5021 - 5022
反应条件
hydrogenchloride; potassium hydroxide; sodium hydroxide; water 1.) 140 deg C, 0.5 h; 250 deg C, 1.5 h; 265 deg C, 0.75 h; allowed to cool to 200 deg C;
参考文献
Martin; Vogel
Tetrahedron, 1980 , vol. 36, # 6 p. 791 - 794
参考文献
Birkinshaw et al.
Biochemical Journal, 1957 , vol. 67, p. 155,161
反应条件
phosphorus; hydrogen iodide
参考文献
Birkinshaw et al.
Biochemical Journal, 1952 , vol. 50, p. 610,624
反应条件
1: K2CO3; acetone 2: acetone; KMnO4 3: aqueous HBr View Scheme
参考文献
Birkinshaw et al.
Biochemical Journal, 1957 , vol. 67, p. 155,161
反应条件
1: acetone; KMnO4 2: aqueous HBr View Scheme
参考文献
Birkinshaw et al.
Biochemical Journal, 1957 , vol. 67, p. 155,161
反应条件
1: KMnO4; aqueous NaHCO3 2: aqueous NaOH 3: aqueous HI; red phosphorus View Scheme
参考文献
Birkinshaw et al.
Biochemical Journal, 1952 , vol. 50, p. 610,624
