6-甲氧基-2,3-二氨基吡啶盐酸盐合成路线

73896-36-32-氨基-6-甲氧基-3-硝酸吡啶→28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐

参考文献

PURDUE PHARMA L.P.; SHIONOGI and CO., LTD.
Patent: WO2008/89201 A2, 2008 ;
Location in patent: Page/Page column 254 ;
WO 2008/089201 A2

27048-04-02-氨基-3-硝基-6-氯吡啶→28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐

参考文献

VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;

16013-85-72,6-二氯-3-硝基吡啶→28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐

参考文献

VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;

2402-78-02,6-二氯吡啶→28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐

参考文献

VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;

75-15-0二硫化碳+28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐→113713-60-32-巯基-5-甲氧基咪唑[4,5-b]吡啶

参考文献

Freitag, Marcus; Schemies, Joerg; Larsen, Tim; El Gaghlab, Khattab; Schulz, Felix; Rumpf, Tobias; Jung, Manfred; Link, Andreas
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3669 - 3677

924-44-7乙醛酸乙酯+28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐→917344-37-76-甲氧基吡啶并[2,3-b]吡嗪-3(4h)-酮

参考文献

VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
Location in patent: Page/Page column 48 ;

924-44-7乙醛酸乙酯+28020-38-46-甲氧基-2,3-二氨基吡啶盐酸盐→

参考文献

Reck, Folkert; Alm, Richard; Brassil, Patrick; Newman, Joseph; Dejonge, Boudewijn; Eyermann, Charles J.; Breault, Gloria; Breen, John; Comita-Prevoir, Janelle; Cronin, Mark; Davis, Hajnalka; Ehmann, David; Galullo, Vincent; Geng, Bolin; Grebe, Tyler; Morningstar, Marshall; Walker, Phil; Hayter, Barry; Fisher, Stewart
Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7834 - 7847