反应条件
1: 1.) NaCH2SOCH3 / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 1 h 2: diethyl ether; methanol 3: DIBAL-H / CH2Cl2 / 0.5 h / 0 °C 4: H2 / PtO2 / methanol / 2585.7 Torr 5: NBS, Ph3P / CH2Cl2 / 0.42 h / 0 - 20 °C View Scheme
参考文献
Gribble, Andrew D.; Dolle, Roland E.; Shaw, Antony; McNair, David; Novelli, Riccardo; Novelli, Christine E.; Slingsby, Brian P.; Shah, Virendra P.; Tew, David; Saxty, Barbara A.; Allen, Mark; Groot, Pieter H.; Pearce, Nigel; Yates, John
Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3569 - 3584