3,6-二甲基-1,2-苯二酚合成路线 （共 25 条）
反应条件
1: 83 percent / K2CO3 / dimethylformamide / 24 h / 100 °C
2: 1.) POCl3 / 1.) 40-45 deg C, 45 min, 2.) r.t., 16 h, then 70 deg C, 6 h
3: 1.) 30percent H2O2, 85percent HCOOH, 2.) NaOH / 1.) -5 deg C, 3-4 h then -10 deg C, 16 h, 2.) 50 deg C, 30 min
View Scheme
参考文献
Dallacker; Coerver
1983 , vol. 38, # 10 p. 1243 - 1248
反应条件
1: 49.2 percent / K2CO3, Cu, glycerine / 8 h / 195 °C
2: 1.) POCl3 / 1.) 40-45 deg C, 45 min, 2.) r.t., 16 h, then 70 deg C, 6 h
3: 1.) 30percent H2O2, 85percent HCOOH, 2.) NaOH / 1.) -5 deg C, 3-4 h then -10 deg C, 16 h, 2.) 50 deg C, 30 min
View Scheme
参考文献
Dallacker; Coerver
1983 , vol. 38, # 10 p. 1243 - 1248
反应条件
1: 34 percent / K2CO3, Cu, glycerine / 8 h / 195 °C
2: 1.) POCl3 / 1.) 40-45 deg C, 45 min, 2.) r.t., 16 h, then 70 deg C, 6 h
3: 1.) 30percent H2O2, 85percent HCOOH, 2.) NaOH / 1.) -5 deg C, 3-4 h then -10 deg C, 16 h, 2.) 50 deg C, 30 min
View Scheme
参考文献
Dallacker; Coerver
1983 , vol. 38, # 10 p. 1243 - 1248
反应条件
1: 64 percent / AlCl3 / benzene / 0.33 h / 60 °C
2: 92 percent / KI, K2CO3 / acetone / 7 h / Heating
3: 64 percent / NH4OAc / acetic acid / 1.5 h / Heating
4: 48 percent / Cu(NO3)2*3H2O / acetic anhydride / 1.25 h / 60 - 65 °C
5: 90 percent / silica gel, Fe / acetic acid; toluene / 1 h / Heating
View Scheme
参考文献
Sinhababu, Achintya K.; Ghosh, Anil K.; Borchardt, Ronald T.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1273 - 1279
反应条件
Celite; silver carbonate
参考文献
Miyahara, Yuji; Inazu, Takahiko; Yoshino, Tamotsu
Tetrahedron Letters, 1982 , vol. 23, # 21 p. 2189 - 2190
