3-羟基-2-甲酰基苯并噻吩合成路线 （共 7 条）
反应条件
1.1: magnesium / Reflux 1.2: 0 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / 20 °C 3.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux View Scheme
参考文献
Jeong, Yong-Chul; Ahn, Dae-Jun; Lee, Woo-Sun; Lee, Seung-Han; Ahn, Kwang-Hyun
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 3 p. 1063 - 1066
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C 1.2: 1 h / 20 °C 2.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux View Scheme
参考文献
Jeong, Yong-Chul; Ahn, Dae-Jun; Lee, Woo-Sun; Lee, Seung-Han; Ahn, Kwang-Hyun
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 3 p. 1063 - 1066
反应条件
toluene-4-sulfonic acid in toluene 5 h; Reflux;
参考文献
Jeong, Yong-Chul; Ahn, Dae-Jun; Lee, Woo-Sun; Lee, Seung-Han; Ahn, Kwang-Hyun
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 3 p. 1063 - 1066
反应条件
sulfuric acid T=90°C;
参考文献
Smiles; McClelland
Journal of the Chemical Society, 1921 , vol. 119, p. 1815
反应条件
1: sodium acetate; ethanol View Scheme
参考文献
Rodionow et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948 , p. 536,545
Chem.Abstr., 1949 , p. 2200
反应条件
1: hydrogen chloride; diethyl ether 2: water View Scheme
参考文献
Krollpfeiffer
Justus Liebigs Annalen der Chemie, 1928 , vol. 462, p. 62
Chemische Berichte, 1923 , vol. 56, p. 2363
参考文献
Rodionow et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948 , p. 536,545
Chem.Abstr., 1949 , p. 2200
