4-氯咪唑4,5-C吡啶合成路线 （共 27 条）
反应条件
1: T=20°C; 12 h; 2: With hydrogenchloride; water
参考文献
EP1690863 A1, ;
Page/Page column 120-121 ;
反应条件
trichlorophosphate Reflux;
参考文献
Maiti, Munmun; Persoons, Leentje; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Herdewijn, Piet
ChemMedChem, 2013 , vol. 8, # 6 p. 985 - 993
参考文献
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Patent: WO2007/47793 A2, 2007 ;
Location in patent: Page/Page column 35 ;
反应条件
trifluoroacetic acid T=80°C; 2 h;
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 2: 20.1 g / acetic anhydride / 1.5 h / Heating 3: 15.6 g / trifluoroacetic acid / 2 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 6 p. 1935 - 1941
反应条件
1: 77 percent / POCl3 / 90 - 100 °C 2: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C 3: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 4: 20.1 g / acetic anhydride / 1.5 h / Heating 5: 15.6 g / trifluoroacetic acid / 2 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 6 p. 1935 - 1941
反应条件
1: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C 2: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C 3: 20.1 g / acetic anhydride / 1.5 h / Heating 4: 15.6 g / trifluoroacetic acid / 2 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 6 p. 1935 - 1941
反应条件
1.1: 3 h / 145 °C 1.2: 2 h / 110 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; methanol / 20 °C 3.1: trichlorophosphate / |Reflux View Scheme
参考文献
ChemMedChem, , vol. 8, # 6 p. 985 - 993
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; methanol / 20 °C 2: trichlorophosphate / |Reflux View Scheme
参考文献
ChemMedChem, , vol. 8, # 6 p. 985 - 993
反应条件
1: 20.1 g / acetic anhydride / 1.5 h / Heating 2: 15.6 g / trifluoroacetic acid / 2 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 6 p. 1935 - 1941
