5,5-二甲基-1-己醇合成路线 （共 14 条）
反应条件
sodium tetrahydroborate; titanium(III) chloride; 18-crown-6 ether in tetrahydrofuran T=25°C; 18 h;
参考文献
Hendel, Robert A.; Nomura, Eisaku; Janout, Vaclav; Regen, Steven L.
Journal of the American Chemical Society, 1997 , vol. 119, # 29 p. 6909 - 6918
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Heating;
参考文献
Schulz; Sprung; Kroning
Pharmazie, 1983 , vol. 38, # 5 p. 310 - 313
反应条件
methanesulfonic acid in methanol T=20°C; 0.5 h;
参考文献
Rybczynski, Philip J.; Zeck, Roxanne E.; Dudash Jr., Joseph; Combs, Donald W.; Burris, Thomas P.; Yang, Maria; Osborne, Melville C.; Chen, Xiaoli; Demarest, Keith T.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 196 - 209
参考文献
Sobotka; Stynler
Journal of the American Chemical Society, 1950 , vol. 72, p. 5139,5141
反应条件
1.1: NaH; KI / dimethylformamide / 0 - 20 °C 1.2: dimethylformamide / 12 h / 80 °C 2.1: aq. KOH / ethanol / 12 h / Heating 3.1: 36 percent / 150 °C 4.1: LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Sasse, Astrid; Ligneau, Xavier; Rouleau, Agnes; Elz, Sigurd; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4000 - 4010
反应条件
1: aq. KOH / ethanol / 12 h / Heating 2: 36 percent / 150 °C 3: LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Sasse, Astrid; Ligneau, Xavier; Rouleau, Agnes; Elz, Sigurd; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4000 - 4010
反应条件
1: 36 percent / 150 °C 2: LiAlH4 / diethyl ether / 12 h / Heating View Scheme
参考文献
Sasse, Astrid; Ligneau, Xavier; Rouleau, Agnes; Elz, Sigurd; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4000 - 4010
反应条件
(i) Mg, (ii) /BRN= 102378/; Multistep reaction;
参考文献
Desai,V.R. et al.
Journal of the Chemical Society [Section] B: Physical Organic, 1970 , p. 386 - 388
参考文献
Mallinckrodt Chem Works
Patent: US2151252 , 1935 ;
反应条件
magnesium 1) ether; Yield given. Multistep reaction;
参考文献
Schulz; Sprung; Kroning
Pharmazie, 1983 , vol. 38, # 5 p. 310 - 313
