α-(4-氯苯基)吡啶-2-甲醇合成路线 （共 14 条）
反应条件
1: 1-chloro-4-bromobenzene With magnesium in tetrahydrofuran 2 h; Heating; 2: pyridine-2-carbaldehyde in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
Froimowitz, Mark; Gu, Yonghong; Dakin, Les A.; Nagafuji, Pamela M.; Kelley, Charles J.; Parrish, Damon; Deschamps, Jeffrey R.; Janowsky, Aaron
Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 219 - 232
反应条件
lithium diisopropyl amide in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Yang, Jingyue; Dudley, Gregory B.
Journal of Organic Chemistry, 2009 , vol. 74, # 20 p. 7998 - 8000
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere;
参考文献
Riva; Gagliardi; Martinelli; Passarella; Vigo; Rencurosi
Tetrahedron, 2010 , vol. 66, # 17 p. 3242 - 3247
反应条件
1: pyridine With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl; boron trifluoride diethyl etherate in tetrahydrofuran T=-40°C; 0.25 h; Inert atmosphereSchlenk technique; 2: 4-chlorobenzaldehyde in tetrahydrofuran T=-40 - 25°C; Inert atmosphereSchlenk technique; 3: With ammonia; water; ammonium chloride in tetrahydrofuran Inert atmosphereSchlenk technique;
参考文献
Manolikakes, Sophia M.; Jaric, Milica; Karaghiosoff, Konstantin; Knochel, Paul
Chemical Communications, 2013 , vol. 49, # 21 p. 2124 - 2126
反应条件
1: chlorobenzene With aluminum tribromide in dichloromethane T=0°C; Friedel-Crafts Alkylation; Inert atmosphere; 2: pyridine-2-carbaldehyde in dichloromethane T=20°C; Friedel-Crafts Alkylation; 24.5 h; Inert atmosphereReflux; 3: With sodium hydrogencarbonate in dichloromethane 0.0833333 h;
参考文献
Harikrishnan, Adhikesavan; Selvakumar, Jayaraman; Gnanamani, Elumalai; Bhattacharya, Suman; Ramanathan, Chinnasamy Ramaraj
New Journal of Chemistry, 2013 , vol. 37, # 3 p. 563 - 567
反应条件
6 h; RefluxInert atmosphere;
参考文献
Hirayama, Tasuku; Ueda, Satoshi; Okada, Takahiro; Tsurue, Norihiko; Okuda, Kensuke; Nagasawa, Hideko
Chemistry - A European Journal, 2014 , vol. 20, # 14 p. 4156 - 4162
反应条件
IDCC cells T=25°C; 432 h; also 4-(4-chlorobenzoyl)pyridine, var. immobilized plant cells culture, other time; Product distribution;
参考文献
Takemoto, Masumi; Yamamoto, Yuichi; Achiwa, Kazuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 3 p. 419 - 422
反应条件
water; dihydrogen peroxide; acetic acid
参考文献
Reilly Tar and Chem.Corp.
Patent: US2748141 , 1956 ;
反应条件
sodium hydroxide in water Heating;
参考文献
Yang, Jingyue; Dudley, Gregory B.
Journal of Organic Chemistry, 2009 , vol. 74, # 20 p. 7998 - 8000
反应条件
1: triethylamine / toluene / 1 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine / 3 h / 80 °C View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 34, # 2 p. 549 - 552
