water; lithium hydroxide hydrate in tetrahydrofuran T=20°C; 1 h;

1.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere 2.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere 4.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 5.1: ammonia / methanol / 24 h / Inert atmosphere 6.1: tri-iso-propylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere 7.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere 7.2: Inert atmosphere 8.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7 View Scheme

triethylamine; dicyclohexyl-carbodiimide in chloroform Acylation; 24 h;

tert-butylisonitrile; benzotriazol-1-ol in chloroform T=20°C; Inert atmosphere;

triethylamine in dichloromethane 24 h; Ambient temperature;

acetic acid in tetrahydrofuran 48 h; Ambient temperature;

air; triethylamine; CuCl2*2H2O 144 h; Ambient temperature;

1: 1.) molecular sieves 3 Angstroem / 1.) MeOH, r.t., 2 h, 2.) r.t., 4 d 2: 81 percent / Et3N, air / CuCl2*2H2O / 144 h / Ambient temperature View Scheme

2: 90.5 percent / Et3N; DCC / CHCl3 / 24 h View Scheme

2: 90.5 percent / Et3N; DCC / CHCl3 / 24 h View Scheme