7-甲基-3H-咪唑并[4,5-b]吡啶合成路线 (共 11 条)
反应条件
1: With toluene-4-sulfonic acid T=125°C; 10 h; 2: With hydrogenchloride in water 1 h; Heating / reflux; 3: in water pH=7;
参考文献
UCB S.A.
Patent: WO2006/128692 A2, 2006 ;
Location in patent: Page/Page column 132; 133 ;
反应条件
platinum(IV) oxide; 10 palladium on activated carbon; hydrogen; sodium hydroxide in water P=2585.81 Torr; 0.5 h;
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
iron; ytterbium(III) triflate T=75°C; 3 h;
参考文献
Wang, Fen; Tran-Dube, Michelle; Scales, Stephanie; Johnson, Sarah; McAlpine, Indrawan; Ninkovic, Sacha
Tetrahedron Letters, 2013 , vol. 54, # 31 p. 4054 - 4057
反应条件
1: 52 percent / 3 h / 140 - 150 °C 2: 70 percent / KMnO4, Na2CO3 / H2O / 2 h / Heating 3: Heating View Scheme
参考文献
Bukowski; Janowiec
Pharmazie, 1988 , vol. 43, # 5 p. 315 - 317
反应条件
1: 70 percent / KMnO4, Na2CO3 / H2O / 2 h / Heating 2: Heating View Scheme
参考文献
Bukowski; Janowiec
Pharmazie, 1988 , vol. 43, # 5 p. 315 - 317
反应条件
1.1: 1,3-dibromo-5,5-dimethyl-hydantoin / dichloromethane / 0.5 h / -45 °C 1.2: -45 - 22 °C 2.1: sulfuric acid; nitric acid / -10 - 22 °C 3.1: sulfuric acid / 2 h / 22 °C 3.2: 22 °C 4.1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 5.1: 1 h / Erfllectrochemical reaction 6.1: 10 palladium on activated carbon; platinum(IV) oxide; hydrogen; sodium hydroxide / water / 0.5 h / 2585.81 Torr View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1.1: sulfuric acid; nitric acid / -10 - 22 °C 2.1: sulfuric acid / 2 h / 22 °C 2.2: 22 °C 3.1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 4.1: 1 h / Erfllectrochemical reaction 5.1: 10 palladium on activated carbon; platinum(IV) oxide; hydrogen; sodium hydroxide / water / 0.5 h / 2585.81 Torr View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: 1 h / Erfllectrochemical reaction 2: 10 palladium on activated carbon; platinum(IV) oxide; hydrogen; sodium hydroxide / water / 0.5 h / 2585.81 Torr View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 2: 1 h / Erfllectrochemical reaction 3: 10 palladium on activated carbon; platinum(IV) oxide; hydrogen; sodium hydroxide / water / 0.5 h / 2585.81 Torr View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
参考文献
Bukowski; Janowiec
Pharmazie, 1988 , vol. 43, # 5 p. 315 - 317