1-氨基-1-环己基甲酸合成路线 （共 42 条）
反应条件
hydrogenchloride Destillieren des Hydrochlorids nach Zusatz von Bleihydroxyd unter vermindertem Druck;
参考文献
Zelinsky; Annenkow; Kulikow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1911 , vol. 43, p. 1095
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1911 , vol. 73, p. 463
反应条件
1: NaOH 2: (i) Et3N, ClCO2Et, THF, (ii) NH3 3: H2 / Pd-C / methanol; H2O View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 5, p. 531 - 540
反应条件
tetreamethyl ammonium hydroxide in 1,4-dioxane 96 h; Ambient temperature;
参考文献
Galoppini, Claudia; Meini, Stefania; Tancredi, Mariella; Di Fenza, Armida; Triolo, Antonio; Quartara, Laura; Maggi, Carlo A.; Formaggio, Fernando; Toniolo, Claudio; Mazzucco, Silvia; Papini, Annamaria; Rovero, Paolo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 409 - 414
反应条件
in 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; alumina-filtered dioxane; ethyl acetate
参考文献
American Home Products Corporation
Patent: US5385910 A1, 1995 ;
反应条件
hydrogenchloride; zinc in water; acetonitrile
参考文献
Babu, Vommina V. Suresh; Ananda, Kuppanna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2001 , vol. 40, # 1 p. 70 - 74
反应条件
sodium hydroxide in water 2 h;
参考文献
Bayer Corporation
Patent: US6353006 B1, 2002 ;
Location in patent: Page column 29 ;
US 6353006 B1
反应条件
1: SOCl2 / r.t., 15 h, reflux, 1 h
2: 35 percent / pyridine / r.t., 12 h, reflux, 8 h
View Scheme
参考文献
Courtoison; Coudert; Couquelet; Tronche; Jonadet; Bastide
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 2 p. 153 - 160
反应条件
1: hydrogen chloride gas / Heating
2: CHCl3 / 3 h / 0 - 20 °C
3: 78 percent / aq. lithium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C
View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1.1: tetrahydrofuran / 3 h / 50 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Schaefer, Gabriel; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 5 p. 1526 - 1529
反应条件
triethylamine in N,N-dimethyl-formamide
参考文献
SEIKAGAKU CORPORATION
Patent: US2009/111983 A1, 2009 ;
Location in patent: Page/Page column 47 ;
US 20090111983 A1
