1-氨基-1-环己基甲酸合成路线 （共 42 条）
参考文献
Langheld
Patent: DE226227 ;
反应条件
methanol in tetrahydrofuran T=0°C;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION
Patent: WO2008/4698 A2, 2008 ;
Location in patent: Page/Page column 130 ;
反应条件
1: With thionyl chloride T=-10 - 20°C; 144 h; Inert atmosphere; 2: With sodium hydrogencarbonate in diethyl ether; water T=0°C; Saturated solution;
参考文献
Hayashi, Shigeo; Nakata, Eriko; Morita, Asato; Mizuno, Kunihiko; Yamamura, Kenzo; Kato, Aki; Ohashi, Katsuyo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7675 - 7699
反应条件
thionyl chloride in methanol; water
参考文献
Aventis Pharma Deutschland GmbH
Patent: US6399643 B1, 2002 ;
反应条件
1: 1-amino-1-cyclo-hexanecarboxylic acid With lithium aluminium tetrahydride in tetrahydrofuran T=70 - 80°C; 28 h; 2: di-tert-butyl dicarbonate With TEA in methanol T=20°C; 4 h;
参考文献
Mutulis, Felikss; Yahorava, Sviatlana; Mutule, Ilze; Yahorau, Aleh; Liepinsh, Edvards; Kopantshuk, Sergei; Veiksina, Santa; Tars, Kaspars; Belyakov, Sergey; Mishnev, Anatoly; Rinken, Ago; Wikberg, Jarl E. S.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4613 - 4626
反应条件
1: hydrogen chloride gas / Heating 2: CHCl3 / 3 h / 0 - 20 °C 3: 71 percent / tetrahydrofuran / 3 h / 0 - 20 °C 4: 85 percent / concd. HCl; glacial acetic acid / 5 h / Heating View Scheme
参考文献
Nabil Aboul-Enein; El-Azzounya; Maklad; Attia; Wiese
Scientia Pharmaceutica, 2001 , vol. 69, # 4 p. 329 - 350
反应条件
1: CH2Cl2 2: H2O View Scheme
参考文献
Kuroda, Yasuhisa; Ueda, Hiroshi; Nozawa, Hiroshi; Ogoshi, Hisanobu
Tetrahedron Letters, 1997 , vol. 38, # 45 p. 7901 - 7904
反应条件
1: With potassium carbonate in methanol; water T=0 - 20°C; 16 h; 2: With hydrogenchloride in water T=0°C; pH=5;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
Location in patent: Page/Page column 114 ;
WO 2012/119941 A1
参考文献
Hoffmann-La Roche Inc.
Patent: US5250517 A1, 1993 ;
US 5250517 A
参考文献
The Boots Company PLC
Patent: US5610161 A1, 1997 ;
