1-氨基-1-环己基甲酸合成路线 （共 42 条）
反应条件
Ba(OH)2·8H2O; water in water T=160°C; 2 h; Autoclave;
参考文献
Stoyanov, Neyko; Marinov, Marin
Acta Chimica Slovenica, 2012 , vol. 59, # 3 p. 680 - 685,6
Title/Abstract Full Text Show Details
Stoyanov, Neyko; Marinov, Marin
Acta Chimica Slovenica, 2012 , vol. 59, # 3 p. 680 - 685
反应条件
barium carbonate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform; sulfuric acid
参考文献
Kidani; Yoshinori
Patent: US4255347 A1, 1981 ;
反应条件
sulfuric acid T=120°C;
参考文献
Wang, Boyuan; Zhang, Wei; Zhang, Leilei; Du, Da-Ming; Liu, Gang; Xu, Jiaxi
European Journal of Organic Chemistry, 2008 , # 2 p. 350 - 355
反应条件
1: 82 percent / ethanol; H2O / 6 h / Heating 2: 68 percent / 3 N aq. NaOH / Heating View Scheme
参考文献
Aboul-Enein, M. N.; El-Azzouny, A. A.; Abdallah, N. A.; Makhlouf, A. A.
Egyptian Journal of Chemistry, 1991 , vol. 34, # 6 p. 549 - 558
反应条件
1: Et3N / CH2Cl2; petroleum ether 2: CH2Cl2 3: (i) aq. HCl, EtOH, (ii) methyloxirane, MeOH View Scheme
参考文献
Krzyzanowska,B.; Stec,W.J.
Synthesis, 1978 , p. 521 - 524
反应条件
1: CH2Cl2 2: (i) aq. HCl, EtOH, (ii) methyloxirane, MeOH View Scheme
参考文献
Krzyzanowska,B.; Stec,W.J.
Synthesis, 1978 , p. 521 - 524
反应条件
1: ammonia 2: aqueous sulfuric acid / 120 °C View Scheme
参考文献
Bucherer; Brandt
Journal fuer Praktische Chemie (Leipzig), 1934 , vol. <2> 140, p. 129,135, 150
反应条件
ethylenediaminetetraacetic acid; phenyl-methyl-sulfonyl fluoride; water in aq. phosphate buffer T=30°C; Microbiological reactionEnzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Maurs, Michele; Acher, Francine; Azerad, Robert
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 22 - 26
反应条件
(i) aq. HCl, EtOH, (ii) methyloxirane, MeOH; Multistep reaction;
参考文献
Krzyzanowska,B.; Stec,W.J.
Synthesis, 1978 , p. 521 - 524
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 12 h; HeatingRefluxInert atmosphere; 2: With water; sodium carbonate in tetrahydrofuran T=0 - 20°C;
参考文献
JANSSEN PHARMACEUTICA NV; PLAYER, Mark, R.; PARKS, Daniel, J.; PARSONS, William; MEEGALLA, Sanath, K; ILLIG, Carl, R.; BALLENTINE, Shelley, K.
Patent: WO2010/45166 A1, 2010 ;
Location in patent: Page/Page column 78-79 ;
