4-甲基-2-(苯基甲基氨基)戊酸合成路线 （共 10 条）
反应条件
1: aq. HCO2H 2: H2 / Pd-C / acetic acid View Scheme
参考文献
Quitt,P. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 327 - 333
反应条件
C24H29CoN2O4 in dichloromethane; water
T=10°C; 24 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Dzygiel, Pawel; Reeve, Toby B.; Piarulli, Umberto; Krupicka, Martin; Tvaroska, Igor; Gennari, Cesare
European Journal of Organic Chemistry, 2008 , # 7 p. 1253 - 1264
反应条件
sodium tetrahydroborate in methanol
0.5 h;
参考文献
Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519
反应条件
potassium carbonate in water
T=20°C; Alkylation; 25 h;
参考文献
Shao, Hua-Wu; Wu, Yikang; Li, Rongxiu
Synthetic Communications, 2000 , vol. 30, # 11 p. 1911 - 1915
反应条件
{Rh[(R,R)-Deguphos](COD)}BF4; hydrogen in methanol; dichloromethane
T=20°C; P=45003.6 Torr; 2 h; Title compound not separated from byproducts;
参考文献
Kadyrov, Renat; Riermeier, Thomas H.; Dingerdissen, Uwe; Tararov, Vitali; Boerner, Armin
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4067 - 4070
反应条件
1: With sodium hydroxide; water
T=20°C;
2: With sodium tetrahydroborate
T=0°C;
参考文献
Lelais, Gerald; Seebach, Dieter
Helvetica Chimica Acta, 2003 , vol. 86, # 12 p. 4152 - 4168
反应条件
in dichloromethane; water
T=10°C; 24 h;
参考文献
Reeve, Toby B.; Cros, Jean-Philippe; Gennari, Cesare; Piarulli, Umberto; De Vries, Johannes G.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 15 p. 2449 - 2453
反应条件
1.1: lithium hydroxide hydrate / methanol / 0.33 h / 20 °C
1.2: 1 h
2.1: sodium tetrahydroborate / methanol / 0.5 h
View Scheme
参考文献
Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519
反应条件
1.1: lithium hydroxide hydrate / methanol / 0.33 h / 20 °C
1.2: 1 h
2.1: sodium tetrahydroborate / methanol / 0.5 h
View Scheme
参考文献
Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519
反应条件
anschliessender Hydrierung an Palladium in Methanol und folgende Hydrolyse;
参考文献
Velluz et al.
Bulletin de la Societe Chimique de France, 1954 , p. 1015
