1: With neopentylmagnesium bromide; cobalt(II) dibromide; 1,3-Diisopropyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate in tetrahydrofuran T=0 - 20°C; 6 h; Schlenk techniqueInert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran Inert atmosphereSchlenk technique;

1: With neopentylmagnesium bromide; cobalt(II) dibromide; 1,3-Diisopropyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate in tetrahydrofuran T=0 - 20°C; 6 h; Schlenk techniqueInert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran Inert atmosphereSchlenk technique; Overall yield = 68 percent;

1: With neopentylmagnesium bromide; cobalt(II) dibromide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide in tetrahydrofuran T=0 - 20°C; 24 h; Schlenk techniqueInert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran Schlenk techniqueInert atmosphere; Overall yield = 19 percent;

1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (S)-3,3'-bis(2,4,6-iPr3-phenyl)-BINOL cyclic phosphate / toluene / 45 h / 35 °C 2: CAN; H2O / methanol / 0 °C View Scheme

copper diacetate; palladium diacetate in dimethyl sulfoxide T=40°C; 12 h; Inert atmosphere; Reagent/catalystTimeTemperatureSolvent;

1: phenyl-magnesium bromide With ZnCl2*TMEDA in tetrahydrofuran T=0°C; Inert atmosphere; 2: N-(4-methoxy-phenyl)-(1-phenyl-ethylidene)-amine With iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran T=0°C; 20 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran T=20°C; 3 h; chemoselective reaction;

iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane; magnesium; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane T=0°C; 24 h; Inert atmosphere;

1: With neopentylmagnesium bromide; cobalt(II) dibromide; diethylphosphinoethane in tetrahydrofuran T=0 - 80°C; 24 h; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 1 h;

1: With neopentylmagnesium bromide; cobalt(II) dibromide; 1,3-Diisopropyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate in tetrahydrofuran T=0 - 20°C; 6 h; Schlenk techniqueInert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran Inert atmosphereSchlenk technique; Overall yield = 68 percent;

tris(dibenzylideneacetone)dipalladium (0); sodium t-butanolate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane T=110°C; 14 h; Inert atmosphere;