4-甲基-2-硝基苯甲酸合成路线 （共 20 条）
反应条件
1: concentrated sulfuric acid; nitric acid 2: hydrochloric acid / 250 °C 3: tin; hydrochloric acid View Scheme
参考文献
Rozanski
Chemische Berichte, 1889 , vol. 22, p. 2679
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 30 °C / |Inert atmosphere 2: 10 Pd/C; hydrogen / methanol / 24 h / 20 °C View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
1: concentrated sulfuric acid; nitric acid 2: hydrochloric acid / 265 °C View Scheme
参考文献
Rozanski
Chemische Berichte, 1889 , vol. 22, p. 2679
反应条件
1: concentrated sulfuric acid; nitric acid 2: tin; hydrochloric acid View Scheme
参考文献
Claus; Joachim
Justus Liebigs Annalen der Chemie, 1891 , vol. 266, p. 218
反应条件
Adam's catalyst; hydrogen in methanol 3 h;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
参考文献
v. Niementowski; Rozanski
Chemische Berichte, 1888 , vol. 21, p. 1993
Full Text Show Details
Noyes
American Chemical Journal, 1888 , vol. 10, p. 474,483
反应条件
1: oxalyl dichloride / toluene / 2 h / 0 - 26 °C
2: ammonium hydroxide / tetrahydrofuran / 4 h / 0 - 26 °C
3: iron; ammonium chloride / ethanol; water / 2 h / |Reflux
4: 4 h / 110 °C / |Sealed tube
View Scheme
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane
T=20°C;
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
Location in patent: Paragraph 0434; 0435 ;
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 30 °C / |Inert atmosphere
2: 10 Pd/C; hydrogen / methanol / 24 h / 20 °C
3: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
1: concentrated sulfuric acid; nitric acid
2: hydrochloric acid / 250 °C
View Scheme
参考文献
Rozanski
Chemische Berichte, 1889 , vol. 22, p. 2679
