1: 73 percent / Et3N / diethyl ether / 3 h / Ambient temperature 2: 38 percent / Et3N / Pd(PPh3)2Cl2, LiCl / dimethylformamide / 2 h / 55 °C 3: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, -78 deg C, 30 min; -78 deg C to r.t., 10 min 4: 23 percent / NH2OH*HCl, NaOAc / ethanol / Ambient temperature View Scheme

1: 38 percent / Et3N / Pd(PPh3)2Cl2, LiCl / dimethylformamide / 2 h / 55 °C 2: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, -78 deg C, 30 min; -78 deg C to r.t., 10 min 3: 23 percent / NH2OH*HCl, NaOAc / ethanol / Ambient temperature View Scheme

hydroxylamine hydrochloride; sodium acetate in ethanol Ambient temperature;