反应条件
1: K2CO3 / dimethylformamide / 40 °C
2: lithium borohydride / diethyl ether
3: 1.) pyridine, triflic anhydride, 2.) NH4Cl / 1.) diethyl ether, from -50 deg C to -30 deg C, 2.) diethyl ether, from -30 deg C to RT
View Scheme
参考文献
Cantrell, Amanda S.; Engelhardt, Per; Hoegberg, Marita; Jaskunas, S. Richard; Johansson, Nils Gunnar; Jordan, Christopher L.; Kangasmetsae, Jussi; Kinnick, Michael D.; Lind, Peter; Morin Jr., John M.; Muesing; Noreen, Rolf; Oeberg, Bo; Pranc, Paul; Sahlberg, Christer; Ternansky, Robert J.; Vasileff, Robert T.; Vrang, Lotta; West, Sarah J.; Zhang, Hong
Journal of Medicinal Chemistry, 1996 , vol. 39, # 21 p. 4261 - 4274