(S)-(-)-1-(4-溴苯)乙胺合成路线 （共 12 条）
反应条件
6-(1,2:3,4-di-O-isopropylidene-α-D-galactopyranosyl) hydrogen phthalate in isopropyl alcohol Heating;
参考文献
Mereyala, Hari Babu; Fatima, Liyakat; Pola, Pallavi
Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 585 - 587
反应条件
1: With [((R)-tol-binap)RuCl2(DMF)x]; ammonia; ammonium formate in methanol T=85°C; Leuckart-Wallach reaction; 48 h; 2: With hydrogenchloride in ethanol 1 h; Heating; Title compound not separated from byproducts;
参考文献
Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1339 - 1347
反应条件
potassium hydroxide in methanol T=20°C; 2 h;
参考文献
McCombie, Stuart W.; Lin, Sue-Ing; Tagat, Jayaram R.; Nazareno, Dennis; Vice, Susan; Ford, Jennifer; Asberom, Theodros; Leone, Daria; Kozlowski, Joseph A.; Zhou, Guowei; Ruperto, Vilma B.; Duffy, Ruth A.; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 795 - 798
反应条件
lipase CAL-B in tert-butyl methyl ether T=55°C; 19 h; Green chemistry; enantioselective reaction;
参考文献
Simon, Sabine; Groeger, Harald; Osswald, Steffen; Roos, Juergen
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 2012 , vol. 67, # 10 p. 1123 - 1126,4
反应条件
1: 1,3-dibromo-5,5-dimethylhydantoin; MeSO3H / CH2Cl2 / 48 h / 20 °C 2: KOH / methanol / 2 h / 20 °C View Scheme
参考文献
McCombie, Stuart W.; Lin, Sue-Ing; Tagat, Jayaram R.; Nazareno, Dennis; Vice, Susan; Ford, Jennifer; Asberom, Theodros; Leone, Daria; Kozlowski, Joseph A.; Zhou, Guowei; Ruperto, Vilma B.; Duffy, Ruth A.; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 795 - 798
反应条件
Candida antacrtica lipase B T=20°C; Enzymatic reaction; optical yield given as percent ee;
参考文献
Ditrich, Klaus
Synthesis, 2008 , # 14 SPEC. ISS. art. no. C01108SS, p. 2283 - 2287
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 1.2: 18 h / 20 °C 2.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane / 72 h / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
borane-THF; C19H23BNO3(1-)*H(1+) in 1,4-dioxane 72 h; Inert atmosphere; enantioselective reaction;
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / pH 5 / |Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 18 h / 20 °C 3.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane / 72 h / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi; Piccolo, Oreste
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1117 - 1122
