(S)-N-(2,6-二甲苯及)哌啶-2-甲酰胺合成路线 （共 25 条）
反应条件
1: With (2R,3S)-(-)-di-O-benzoyl tartaric acid in isopropyl alcohol T=20°C; 1.5 h; Reflux; 2: With water; sodium hydroxide in ethyl acetate
参考文献
PHARMATHEN S.A.
Patent: WO2009/89842 A1, 2009 ;
Location in patent: Page/Page column 6-7 ;
反应条件
benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane T=20°C; 12 h;
参考文献
Shankaraiah, Nagula; Pilli, Ronaldo Aloise; Santos, Leonardo S.
Tetrahedron Letters, 2008 , vol. 49, # 34 p. 5098 - 5100
反应条件
hydrogen; palladium dichloride in acetic acid; ethyl acetate T=20°C; P=2068.59 Torr; 6 h;
参考文献
Kumar, Sanjeev; Ramachandran, Uma
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 19 - 21
反应条件
hydrogen; potassium carbonate; palladium on activated charcoal in ethanol
参考文献
Adger, Brian; Dyer, Ulrich; Hutton, Gordon; Woods, Martin
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6399 - 6402
反应条件
sodium carbonate T=20°C; 1.5 h;
参考文献
NEON LABORATORIES LIMITED; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan
Patent: WO2014/9964 A1, 2014 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium carbonate T=20°C; 2 h;
参考文献
NEON LABORATORIES LIMITED; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan
Patent: WO2014/9964 A1, 2014 ;
Location in patent: Page/Page column 15 ;
反应条件
sodium hydroxide in water; toluene T=60°C; 1 h; Product distribution / selectivity;
参考文献
GOEL, Ramniwas
Patent: WO2009/44404 A1, 2009 ;
Location in patent: Page/Page column 9-10 ;
反应条件
in acetone T=-30 - 40°C; 12 h; Product distribution / selectivity;
参考文献
Navinta LLC
Patent: US2006/276654 A1, 2006 ;
Location in patent: Page/Page column 4 ;
反应条件
1: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, 0 deg C to 5 deg C, 2) THF, r.t. 2: HCl / CH2Cl2 / 0 - 5 °C View Scheme
参考文献
Adger, Brian; Dyer, Ulrich; Hutton, Gordon; Woods, Martin
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6399 - 6402
反应条件
1: NaNO2 / acetic acid 2: DCC 3: K2CO3 / methanol 4: Et3N 5: 90 percent / H2, K2CO3 / 10percent Pd/C / ethanol View Scheme
参考文献
Adger, Brian; Dyer, Ulrich; Hutton, Gordon; Woods, Martin
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6399 - 6402
