3-(4-硝基苯氧基)苯甲酸合成路线 （共 11 条）
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 50 °C 2: triethylamine / dichloromethane / 20 °C 3: 10 palladium on activated charcoal; hydrogen / methanol / 20 °C View Scheme
参考文献
Lin, Xingyu; Huang, Xi-Ping; Chen, Gang; Whaley, Ryan; Peng, Shiming; Wang, Yanli; Zhang, Guoliang; Wang, Simon X.; Wang, Shaohui; Roth, Bryan L.; Huang, Niu
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5749 - 5759
反应条件
in tetrahydrofuran; water
参考文献
BAYER CORPORATION
Patent: US2003/207872 A1, 2003 ;
Location in patent: Page/Page column 14 ;
US 20030207872 A1
反应条件
potassium carbonate in dimethyl sulfoxide
T=130°C; 12 h;
参考文献
SNU RandDB FOUNDATION; DONGWOO FINE-CHEM CO. LTD
Patent: US2012/46472 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium hydroxide; ammonia in water
参考文献
Bayer Aktiengesellschaft
Patent: US5382686 A1, 1995 ;
反应条件
in tetrahydrofuran; water
参考文献
Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
反应条件
pyridine; potassium permanganate; sodium hydroxide in water
T=100°C; 10.5 h; Reflux;
参考文献
Xia, Lianlian; Zhai, Xuejiao; Xiong, Xuhai; Chen, Ping
RSC Advances, 2014 , vol. 4, # 9 p. 4646 - 4655
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C
1.2: |Heating
2.1: sodium hydroxide; pyridine; potassium permanganate / water / 10.5 h / 100 °C / |Reflux
View Scheme
参考文献
Xia, Lianlian; Zhai, Xuejiao; Xiong, Xuhai; Chen, Ping
RSC Advances, 2014 , vol. 4, # 9 p. 4646 - 4655
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C
1.2: |Heating
2.1: sodium hydroxide; pyridine; potassium permanganate / water / 10.5 h / 100 °C / |Reflux
View Scheme
参考文献
Xia, Lianlian; Zhai, Xuejiao; Xiong, Xuhai; Chen, Ping
RSC Advances, 2014 , vol. 4, # 9 p. 4646 - 4655
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 135 °C
2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 4 h / 50 °C
2.2: pH 2
View Scheme
参考文献
Lin, Xingyu; Huang, Xi-Ping; Chen, Gang; Whaley, Ryan; Peng, Shiming; Wang, Yanli; Zhang, Guoliang; Wang, Simon X.; Wang, Shaohui; Roth, Bryan L.; Huang, Niu
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5749 - 5759
反应条件
4-methyl-morpholine; methylamine in tetrahydrofuran; dichloromethane; ethyl acetate
参考文献
Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
