3-(1-吡咯烷基)巴豆酸乙酯合成路线 （共 11 条）
反应条件
phenyl isocyanate; triethylamine in benzene
参考文献
Jones, Raymond C. F.; Bhalay, Gurdip; Carter, Paul A.; Duller, Kathryn A. M.; Dunn, Stephen H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1999 , # 7 p. 765 - 776
反应条件
1: 4-fluorobezaldoxime With N-chloro-succinimide in N,N-dimethyl-formamide T=20°C; 1.5 h; 2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate in N,N-dimethyl-formamide T=20°C; 28 h;
参考文献
Hoffmann-La Roche Inc.; Dott, Pascal; Grassmann, Olaf; Kammerer, Michael; Manns, Joachim; Schwitter, Urs; Thomas, Andrew; Wyttenbach, Nicole
Patent: US2013/172329 A1, 2013 ;
Location in patent: Paragraph 0257 ;
反应条件
in N,N-dimethyl-formamide T=20°C; 28 h;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; GRASSMANN, Olaf; KAMMERER, Michael; MANNS, Joachim; SCHWITTER, Urs; THOMAS, Andrew; WYTTENBACH, Nicole
Patent: WO2013/57124 A1, 2013 ;
Location in patent: Page/Page column 36 ;
反应条件
hydrogenchloride; toluene-4-sulfonic acid 1.) dioxane, 17 h, 100 deg C, 2.) CHCl3, 11 h; Yield given. Multistep reaction;
参考文献
Gravel, Denis; Labelle, Marc
Canadian Journal of Chemistry, 1985 , vol. 63, p. 1874 - 1883
反应条件
1: Benzaldoxime With pyridine; N-chloro-succinimide in chloroform Heating; 2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate With triethylamine in chloroform
参考文献
Nakamura, Masayuki; Kurihara, Hideki; Suzuki, Gentaroh; Mitsuya, Morihiro; Ohkubo, Mitsuru; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 726 - 729
反应条件
(i), (ii) aq. Na2CO3; Multistep reaction;
参考文献
Sih; Heather; Sood; Price; Peruzzotti; Lee
Journal of the American Chemical Society, 1975 , vol. 97, # 4 p. 865 - 874
反应条件
1: 3-(methyloxy)benzaldehyde oxime With pyridine; N-chloro-succinimide in chloroform
Heating;
2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate With triethylamine in chloroform
参考文献
Nakamura, Masayuki; Kurihara, Hideki; Suzuki, Gentaroh; Mitsuya, Morihiro; Ohkubo, Mitsuru; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 726 - 729
反应条件
triethylamine in ethyl acetate
16 h; Yield given;
参考文献
Jensen, Soeren; Torssell, Kurt B. G.
Acta Chemica Scandinavica, 1995 , vol. 49, # 1 p. 53 - 56
反应条件
1: pyridine-4-carboxaldoxime With pyridine; N-chloro-succinimide in chloroform
T=50°C;
2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate With triethylamine in chloroform
参考文献
Nakamura, Masayuki; Kurihara, Hideki; Suzuki, Gentaroh; Mitsuya, Morihiro; Ohkubo, Mitsuru; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 726 - 729
反应条件
1: o-methoxybenzaldehyde oxime With pyridine; N-chloro-succinimide in chloroform
Heating;
2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate With triethylamine in chloroform
参考文献
Nakamura, Masayuki; Kurihara, Hideki; Suzuki, Gentaroh; Mitsuya, Morihiro; Ohkubo, Mitsuru; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 726 - 729
