3-溴甲基-2-苯基喹啉-4-羧酸甲酯合成路线 （共 6 条）
反应条件
N-bromosuccinmide; acetic acid; dibenzoyl peroxide in tetrachloromethane; benzene 3.5 h; UV-irradiationInert atmosphereReflux;
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
Location in patent: Page/Page column 50-51 ;
反应条件
N-bromosuccinmide in acetonitrile
参考文献
Farina, Carlo; Giardina, Giuseppe; Grugni, Mario; Gerard, Guy Marguerite Marie
Patent: US2004/77658 A1, 2004 ;
反应条件
1.1: oxalyl chloride / CH2Cl2 / 0.5 h / 20 °C 1.2: DMF / CH2Cl2 / 0.5 h 2.1: CH2Cl2 / 18 h 3.1: 70 percent / NBS; dibenzoylperoxide / acetonitrile / 28 h / Heating View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
反应条件
1: CH2Cl2 / 18 h 2: 70 percent / NBS; dibenzoylperoxide / acetonitrile / 28 h / Heating View Scheme
参考文献
Blaney; Raveglia; Artico; Cavagnera; Dartois; Farina; Grugni; Gagliardi; Luttmann; Martinelli; Nadler; Parini; Petrillo; Sarau; Scheideler; Hay; Giardina
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1675 - 1689
反应条件
1.1: potassium hydroxide / ethanol; water / 0.17 h 1.2: 18 h / Reflux 2.1: dichloromethane; hexanes; methanol / 1 h / 0 - 20 °C 3.1: dibenzoyl peroxide; N-bromosuccinmide; acetic acid / benzene; tetrachloromethane / 3.5 h / UV-irradiation; Inert atmosphere; Reflux View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
反应条件
1.1: potassium hydroxide / ethanol; water / 0.17 h 1.2: 18 h / Reflux 2.1: dichloromethane; hexanes; methanol / 1 h / 0 - 20 °C 3.1: dibenzoyl peroxide; N-bromosuccinmide; acetic acid / benzene; tetrachloromethane / 3.5 h / UV-irradiation; Inert atmosphere; Reflux View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
