1H-吡唑并[4,3-b]吡啶合成路线 （共 6 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol T=20°C; 0.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O'YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu
Patent: WO2013/30138 A1, 2013 ;
Location in patent: Page/Page column 253 ;
反应条件
hydrazine T=115°C; 7 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2008/71451 A1, 2008 ;
Location in patent: Page/Page column 52 ;
WO 2008/071451 A1
反应条件
1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine 2: hydrazine 3: 130 °C View Scheme
参考文献
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
参考文献
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
反应条件
1: With bromine; sodium hydroxide in water T=20°C; 3 h; 2: With hydrogenchloride; sodium hydrogensulfite in water
参考文献
MERCK SHARP and DOHME CORP.; LIVERTON, Nigel; JONES, Philip; LEI, Zhiyu; LIU, Fuqing; LUO, Yunfu; DONG, Jingchao; SOLL, Richard
Patent: WO2013/63100 A1, 2013 ;
Location in patent: Paragraph 0086 ;
反应条件
iodine; potassium hydroxide in N,N-dimethyl-formamide
T=0 - 20°C; 2.5 h; regioselective reaction;
参考文献
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
