噻吩并[2,3-b]吡啶合成路线 （共 24 条）
反应条件
1: 2-Nitrothiophene With hydrogenchloride; tin; zinc(II) chloride in ethanol T=85°C; 2: 1,1,3,3-tetraethoxy-propane in ethanol T=85°C; 1 h;
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
Location in patent: Page/Page column 19 ;
US 20120245178 A1
反应条件
sodium hydroxide; zinc Ambient temperature;
参考文献
Meth-Cohn, Otto; Narine, Bramha; Tarnowski, Brian; Hayes, Roy; Keyzad, Amitis; at al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2509 - 2517
反应条件
acetic acid; zinc 1 h; Heating;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 88 percent / m-chloroperbenzoic acid / CH2Cl2 / 24 h / Ambient temperature 2: 24 h / 140 °C 3: 1 M aq. NaHCO3 / acetone / 2 h / 40 °C View Scheme
参考文献
Taylor, Edward C.; Macor, John E.
Journal of Organic Chemistry, 1987 , vol. 52, # 19 p. 4280 - 4287
反应条件
1: 24 h / 140 °C 2: 1 M aq. NaHCO3 / acetone / 2 h / 40 °C View Scheme
参考文献
Taylor, Edward C.; Macor, John E.
Journal of Organic Chemistry, 1987 , vol. 52, # 19 p. 4280 - 4287
反应条件
1: KOH / ethanol / 0.42 h / Heating 2: Cu View Scheme
参考文献
Schneller,S.W. et al.
Journal of Heterocyclic Chemistry, 1976 , vol. 13, p. 273 - 275
反应条件
1: (i) aq. NaNO2, H2SO4, (ii) aq. H3PO2 2: KOH / ethanol / 0.42 h / Heating 3: Cu View Scheme
参考文献
Schneller,S.W. et al.
Journal of Heterocyclic Chemistry, 1976 , vol. 13, p. 273 - 275
反应条件
1: 72 percent / toluene / 3 h / Heating 2: 66 percent / diphenyl ether / 0.17 h / Heating 3: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C 4: 79 percent / Zn, glacial CH3COOH / 1 h / Heating View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 73 percent / NaH / tetrahydrofuran / 3 h / Heating 2: 93 percent / 2M aq. NaOH / 2 h / Heating 3: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C 4: 79 percent / Zn, glacial CH3COOH / 1 h / Heating View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 66 percent / diphenyl ether / 0.17 h / Heating 2: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C 3: 79 percent / Zn, glacial CH3COOH / 1 h / Heating View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
