(2S)-2-(苯甲酰基氨基)-3-(1H-吲哚-3-基)丙酸甲酯合成路线 （共 11 条）
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile 60 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 14 p. 1085 - 1086
反应条件
methyl iodide in methanol 24 h; Ambient temperature;
参考文献
Ishida; Nakamura; Irie; Oh-Ishi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3237 - 3249
反应条件
Boc-Dmaa-D-pro-Aic-Ser(Bn)-NMe2 in toluene
T=4°C; 23 h; enantioselective reaction;
参考文献
Metrano, Anthony J.; Miller, Scott J.
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1542 - 1554
反应条件
zinc trifluoromethanesulfonate in chloroform
T=78°C; 18 h;
参考文献
Sato, Kazuo; Kozikowski, Alan P.
Tetrahedron Letters, 1989 , vol. 30, # 31 p. 4073 - 4076
反应条件
zinc(II) chloride in xylene
Heating;
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Tsubata, Kenji; Uchida, Kenshi; Kanazawa, Takenobu; Tsuda, Kunio
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3711 - 3716
反应条件
potassium carbonate in water; ethyl acetate
1 h; Ambient temperature;
参考文献
Yoshioka, Tadao; Mohri, Kunihiko; Oikawa, Yuji; Yonemitsu, Osamu
Journal of Chemical Research, Miniprint, 1981 , # 7 p. 2252 - 2281
反应条件
Candida antarctica lipase B; triethylamine in toluene
T=37°C; Ring cleavage; Title compound not separated from byproducts;
参考文献
Brown, Stuart A.; Parker, Marie-Claire; Turner, Nicholas J.
Tetrahedron Asymmetry, 2000 , vol. 11, # 8 p. 1687 - 1690
反应条件
1: diisipropylcarbodiimide; 4,4-dimethylaminopyridine / CH2Cl2 / 0.5 h / 20 °C
2: piperidine / dimethylformamide / 0.13 h / 20 °C
3: TEA / CH2Cl2 / 1 h / 20 °C
4: MeONa / 0.17 h / 20 °C
View Scheme
参考文献
Zhang, San-qi; Fukase, Koichi; Kusumoto, Shoichi
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7479 - 7483
反应条件
1: 1.) TFA
2: 38 percent / Zn(OTf)2 / CHCl3 / 18 h / 78 °C
View Scheme
参考文献
Sato, Kazuo; Kozikowski, Alan P.
Tetrahedron Letters, 1989 , vol. 30, # 31 p. 4073 - 4076
反应条件
sodium methylate
T=20°C; methanolysis; 0.166667 h;
参考文献
Zhang, San-qi; Fukase, Koichi; Kusumoto, Shoichi
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7479 - 7483
