7H-吡咯并[2,3-D]嘧啶合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=760.051 Torr; 16 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/41130 A2, 2007 ;
Location in patent: Page/Page column 40; Sheet 1/9 ;
WO 2007/041130 A2
反应条件
potassium hydroxide in aqueous potassium hydroxide
参考文献
PHARMACIA and UPJOHN S.p.A.
Patent: EP795556 A1, 1997 ;
EP 0795556 A1
反应条件
in methanol; methanolic potassium hydroxide
参考文献
PHARMACIA and UPJOHN S.p.A.
Patent: EP795556 A1, 1997 ;
EP 0795556 A1
反应条件
nickel in ammonium hydroxide 0.5 h; Heating;
参考文献
Seela, Frank; Steker, Herbert
Liebigs Annalen der Chemie, 1983 , # 9 p. 1576 - 1587
反应条件
1: 66 percent / POCl3 2: 84 percent / H2 / Pd/C View Scheme
参考文献
Seela, Frank; Steker, Herbert
Liebigs Annalen der Chemie, 1983 , # 9 p. 1576 - 1587
反应条件
1: 64 percent / NaOEt 2: 92 percent / aq. HCl 3: 81 percent / H2 / Raney Ni 4: 66 percent / POCl3 5: 84 percent / H2 / Pd/C View Scheme
参考文献
Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250
反应条件
1: 92 percent / aq. HCl 2: 81 percent / H2 / Raney Ni 3: 66 percent / POCl3 4: 84 percent / H2 / Pd/C View Scheme
参考文献
Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250
反应条件
1: 81 percent / H2 / Raney Ni 2: 66 percent / POCl3 3: 84 percent / H2 / Pd/C View Scheme
参考文献
Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250
反应条件
1: With acetic acid in water 12 h; Reflux; 2: With sodium carbonate in water pH=8 - 9;
参考文献
SBI BIOTECH CO., LTD.; CRYSTALGENOMICS, INC.; FUNAKOSHI, Yoko; TANAKA, Chika; PARK, Choul Hong; RO, Seong Gu
Patent: WO2012/2568 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/002568 A1
反应条件
bromine in N,N-dimethyl-formamide 2 h; Ambient temperature;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Sato, Shuichiroh; Yamanaka, Hiroshi
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 5 p. 459 - 464
