反应条件
1.1: n-heptane; ethylene glycol dimethyl ether / 3 h / 20 °C
2.1: trichlorophosphate / 85 - 90 °C
2.2: pH 9
3.1: zinc / tris-(dibenzylideneacetone)dipalladium(0); [Fe(II)(C5H5)(C5H4PPh2)] / isobutyramide / 2 h / 120 °C / Inert atmosphere
4.1: sodium hydroxide; water / ethanol / 6 h / Reflux
5.1: trichlorophosphate / Reflux
5.2: pH 9
6.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux
View Scheme
参考文献
ASCEPION PHARMACEUTICALS, INC.; JIANG, Shan; XING, Xinglong; WANG, Qishan; KONG, Ren
Patent: WO2011/23081 A1, 2011 ;
WO 2011/023081 A1