氯代双(4-氟苯基甲烷)合成路线 （共 13 条）
反应条件
thionyl chloride in toluene 2 h; Heating;
参考文献
Valenta, Vladimir; Urban, Jiri; Taimr, Jan; Polivka, Zdenek
Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 5 p. 1126 - 1136
参考文献
Sankyo Company Limited
Patent: US5028610 A1, 1991 ;
反应条件
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C View Scheme
参考文献
Shivprakash; Reddy, G. Chandrasekara
Synthetic Communications, 2014 , vol. 44, # 5 p. 600 - 609
反应条件
2: SOCl2 View Scheme
参考文献
Gascoyne,J.M. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977 , p. 1051 - 1057
反应条件
2: SOCl2 View Scheme
参考文献
Gascoyne,J.M. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977 , p. 1051 - 1057
反应条件
1: acetonitrile / 1.5 h / 80 °C 2: H2, NH3, Raney nickel / ethanol / 5 h / 60 °C / 45600 Torr 3: 52.5 percent / NaBH3CN, HCl, 3 Angstroem molecular sieves / methanol / 24 h / Ambient temperature View Scheme
参考文献
Dhainaut, Alain; Regnier, Gilbert; Atassi, Ghanem; Pierre, Alain; Leonce, Stephane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2481 - 2496
反应条件
1: 0.33 h / Reflux 2: Ru(bpy)3Cl2; caesium carbonate / N,N-dimethyl acetamide / 48 h / 25 °C / Irradiation View Scheme
参考文献
Su, Yijin; Zhang, Liangren; Jiao, Ning
Organic Letters, 2011 , vol. 13, # 9 p. 2168 - 2171
反应条件
in 1,4-dioxane 7 h; Heating;
参考文献
Weiwer, Michel; Bittker, Joshua A.; Lewis, Timothy A.; Shimada, Kenichi; Yang, Wan Seok; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Stockwell, Brent R.; Schreiber, Stuart L.; Munoz, Benito
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1822 - 1826
反应条件
1: piperazine Dihydrochloride With potassium carbonate in N,N-dimethyl-formamide 0.166667 h; 2: bis(4-fluorophenyl)methyl chloride in N,N-dimethyl-formamide T=80°C; 8 h;
参考文献
Santhoshi, Amlipur; Kumar, Singam Naveen; Sujitha, Pombala; Poornachandra, Yedla; Sadhu, Partha Sarathi; Kumar, C. Ganesh; Rao, Vaidya Jayathirtha
Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3207 - 3219
反应条件
1: 49 percent / Et3N / CHCl3 / 6 h / Heating 2: 71 percent / KOH / ethanol / 3 h / Heating View Scheme
参考文献
Valenta, Vladimir; Urban, Jiri; Taimr, Jan; Polivka, Zdenek
Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 5 p. 1126 - 1136
