外消旋安非他命盐酸盐溴化物合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon P=2587.76 Torr;
参考文献
BOEHRINGER INGELHEIM CHEMICALS INC
Patent: JP2005/507936 A, 2005 ;
Location in patent: Page/Page column 13-14 ;
反应条件
hydrogenchloride in benzene Ambient temperature;
参考文献
Koziara, Anna; Olejniczak, Bogdan; Osowska, Krystyna; Zwierzak, Andrzej
Synthesis, 1982 , # 11 p. 918 - 920
反应条件
hydrogenchloride in benzene
参考文献
Krzyzanowska, B.; Stec, W. J.
Synthesis, 1982 , # 4 p. 270 - 273
反应条件
1: chlorobenzene; diethyl ether / 1 h / 0 °C 2: aq. HCl / ethanol / 6 h / Heating View Scheme
参考文献
Kitamura, Mitsuru; Suga, Takahiro; Chiba, Shunsuke; Narasaka, Koichi
Organic Letters, 2004 , vol. 6, # 24 p. 4619 - 4621
反应条件
phosphorus; hydrogen iodide T=40 - 100°C; 2 - 22 h;
参考文献
BOEHRINGER INGELHEIM CHEMICALS INC
Patent: JP2005/507936 A, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 1.) Hg(NO3)2, 2.) 10percent aq NaOH, NaBH4 / 1.) CH3CHCl2, reflux, 4 h, 2.) room temp., 1 h 2: 64 percent / hydrogen chloride / benzene / Ambient temperature View Scheme
参考文献
Koziara, Anna; Olejniczak, Bogdan; Osowska, Krystyna; Zwierzak, Andrzej
Synthesis, 1982 , # 11 p. 918 - 920
反应条件
1: 21 percent / LiAlH4, (-)-quinine / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: 75 percent / HCl / benzene View Scheme
参考文献
Krzyzanowska, B.; Stec, W. J.
Synthesis, 1982 , # 4 p. 270 - 273
反应条件
1: 75 percent / triethylamine / CH2Cl2; petroleum ether / -40 - -15 °C 2: 21 percent / LiAlH4, (-)-quinine / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 3: 75 percent / HCl / benzene View Scheme
参考文献
Krzyzanowska, B.; Stec, W. J.
Synthesis, 1982 , # 4 p. 270 - 273
反应条件
in water T=50°C; 2 h; 2 h addition at 50 deg C; Yield given;
参考文献
Kienzle; Bounameaux; Minder; Muggli
Helvetica Chimica Acta, 1986 , vol. 69, # 7 p. 1671 - 1680
参考文献
Yashunskii; Gorkin; Mashkovskii; Altshuler; Veryovkina; Kholodov
Journal of medicinal chemistry, 1971 , vol. 14, # 10 p. 1013 - 1015
