2-氨基-3-硝基-6-氯吡啶合成路线 （共 36 条）
反应条件
1: With hydrogen bromide in water; acetic acid T=100°C; 26 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2004/2986 A2, 2004 ;
Location in patent: Page 127-128 ;
WO 2004/002986 A2
反应条件
1: 70 percent / NaOMe / 2 h / Heating 2: H2 / 10percent Pd/C / ethanol / 760 Torr View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
in methanol T=15 - 30°C; 4 - 5 h;
参考文献
JUBILANT ORGANOSYS LIMITED
Patent: US2006/80790 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
methanol; sodium 2 h; Heating / reflux;
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
sodium methylate 2 h; Heating;
参考文献
Ohmori; Kubota; Shimizu-Sasamata; Okada; Sakamoto
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1331 - 1338
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; water; toluene T=90°C; 12 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1460067 A1, 2004 ;
Location in patent: Page 43 ;
反应条件
acetic anhydride in tetrahydrofuran; hexane; dichloromethane
参考文献
Nuss, John M.; Harrison, Stephen D.; Ring, David B.; Boyce, Rustum S.; Johnson, Kirk; Pfister, Keith B.; Ramurthy, Savithri; Seely, Lynn; Wagman, Allan S.; Desai, Manjo; Levine, Barry H.
Patent: US2002/156087 A1, 2002 ;
US 20020156087 A1
反应条件
sulfuric acid; acetic acid 2 h; Heating;
参考文献
Radl, Stanislav; Hradil, Pavel
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2420 - 2429
反应条件
1: triethylamine / dioxane
2: H2 / Raney nickel / dioxane / 50 °C / 3750.3 Torr
View Scheme
参考文献
Emig; Nickel; Weischer; Szelenyi; Engel
Arzneimittel-Forschung/Drug Research, 1993 , vol. 43, # 6 p. 627 - 631
反应条件
iodine; silver sulphate in ethanol
T=20°C;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2007/39297 A1, 2007 ;
Location in patent: Page/Page column 28 ;
WO 2007/039297 A1
