2,2,2-三氟-1-(2-甲氧基苯基)乙酮合成路线 （共 14 条）
反应条件
1.1: tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere; |Sealed tube
1.2: 0 - 20 °C / |Inert atmosphere; |Sealed tube
1.3: 0 - 20 °C / |Inert atmosphere; |Sealed tube
2.1: oxoammonium salt; 2,6-dimethylpyridine / dichloromethane / 20 °C / |Sealed tube
View Scheme
参考文献
Kelly, Christopher B.; Mercadante, Michael A.; Hamlin, Trevor A.; Fletcher, Madison H.; Leadbeater, Nicholas E.
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8131 - 8141
反应条件
1.1: potassium iodide; sulfuric acid; dihydrogen peroxide / methanol / 12 h / 0 - 20 °C / |Inert atmosphere
2.1: potassium carbonate / acetone / 8 h / 0 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran / 9 h / -78 °C / |Inert atmosphere
3.2: 4 h / -78 °C / |Inert atmosphere
View Scheme
参考文献
Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo-Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong-Sub; Won, Misun
Angewandte Chemie - International Edition, 2013 , vol. 52, # 39 p. 10286 - 10289
Angew. Chem., 2013 , vol. 125, # 39 p. 10476 - 10479
反应条件
1.1: potassium carbonate / acetone / 8 h / 0 - 20 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 9 h / -78 °C / |Inert atmosphere
2.2: 4 h / -78 °C / |Inert atmosphere
View Scheme
参考文献
Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo-Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong-Sub; Won, Misun
Angewandte Chemie - International Edition, 2013 , vol. 52, # 39 p. 10286 - 10289
Angew. Chem., 2013 , vol. 125, # 39 p. 10476 - 10479
反应条件
(i) Mg, (ii) /BRN= 742035/; Multistep reaction;
参考文献
Lapkin,I.I. et al.
Journal of Organic Chemistry USSR (English Translation), 1970 , vol. 6, p. 233 - 235
Zhurnal Organicheskoi Khimii, 1970 , vol. 6, # 2 p. 241 - 243
