2,2,2-三氟-1-(2-甲氧基苯基)乙酮合成路线 （共 14 条）
反应条件
bromo magnesium butylate
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 107 ;
US 20050176701 A1
反应条件
1: diethylzinc With C58H44N2 in n-heptane; toluene T=-20°C; 0.5 h; Inert atmosphere; 2: 2,2,2-trifluoro-1-(2-methoxyphenyl)ethan-1-one in n-heptane; toluene T=-40°C; 72 h; Inert atmosphere; enantioselective reaction;
参考文献
Calvillo-Barahona, Mercedes; Cordovilla, Carlos; Genov, Miroslav N.; Martinez-Ilarduya, Jesus M.; Espinet, Pablo
Dalton Transactions, 2013 , vol. 42, # 40 p. 14576 - 14582
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: 2,2,2-trifluoro-1-(2-methoxyphenyl)ethan-1-one in tetrahydrofuran; diethyl ether T=20°C; 3 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate
18 h; Reflux;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1: in diethyl ether
T=-78 - 20°C; 12 h;
2: With ammonium chloride in diethyl ether; water
T=-78°C;
参考文献
PFIZER INC.
Patent: WO2006/18725 A1, 2006 ;
Location in patent: Page/Page column 155-156 ;
WO 2006/018725 A1
反应条件
in diethyl ether
T=-78 - 20°C; 12 h;
参考文献
PFIZER INC.
Patent: WO2004/74270 A2, 2004 ;
Location in patent: Page 229-230 ;
反应条件
tributylphosphine; palladium diacetate in 1-methyl-pyrrolidin-2-one
T=80°C; 4 h;
参考文献
Kakino; Shimizu; Yamamoto
Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 2 p. 371 - 376
反应条件
1: 2-methoxybromobenzene With iodine; magnesium in tetrahydrofuran
2 h; Heating;
2: N-(trifluoroacetyl)piperidine T=0 - 20°C; 2 h;
参考文献
Schenck, Hilary A.; Lenkowski, Paul W.; Choudhury-Mukherjee, Indrani; Ko, Seong-Hoon; Stables, James P.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 979 - 993
反应条件
1: 1-iodo-2-methoxybenzene With n-butyllithium in tetrahydrofuran
T=-78°C; 9 h; Inert atmosphere;
2: N-(trifluoroacetyl)piperidine in tetrahydrofuran
T=-78°C; 4 h; Inert atmosphere;
参考文献
Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo-Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong-Sub; Won, Misun
Angewandte Chemie - International Edition, 2013 , vol. 52, # 39 p. 10286 - 10289
Angew. Chem., 2013 , vol. 125, # 39 p. 10476 - 10479
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
