2,3,5,6-四氟吡啶-4-醇合成路线 （共 13 条）
反应条件
potassium hydroxide in tert-butyl alcohol 1.5 h, reflux;;
参考文献
Banks, R. E.; Burgess, J. E.; Cheng, W. M.; Haszeldine, R. N.
Journal of the Chemical Society, 1965 , p. 575 - 594
Full Text Show Details
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
Full Text Show Details
Haszeldine, R. N.; Banks, R. E.
Patent: US3317542 , 1967 ;
C.A., 1968 , vol. 68, p. 59442
反应条件
hydrogen iodide in water 54 percent aq. HI; 3 h, reflux;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
反应条件
potassium fluoride in sulfolane T=137 - 140°C; 17 h; Yield given;
参考文献
Brooke, Gerald M.
Journal of Fluorine Chemistry, 1983 , vol. 22, p. 483 - 492
反应条件
[N-butylthiazolium][Br]; zinc in water T=70°C; 7 h;
参考文献
Prikhod'ko, Sergey A.; Adonin, Nicolay Yu.; Parmon, Valentin N.
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2265 - 2268
反应条件
NiCl2*2Phen; [N-butylthiazolium][Br]; zinc in water T=70°C; 7 h;
参考文献
Prikhod'ko, Sergey A.; Adonin, Nicolay Yu.; Parmon, Valentin N.
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2265 - 2268
反应条件
NiCl2*3Bpy; [N-butylthiazolium][Br]; zinc in water T=70°C; 7 h;
参考文献
Prikhod'ko, Sergey A.; Adonin, Nicolay Yu.; Parmon, Valentin N.
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2265 - 2268
反应条件
1: neat (no solvent) 2: sodium hydroxide View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
2: steel wool / neat (no solvent) 3: sodium hydroxide View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
in sodium hydroxide 7 percent aq. NaOH soln., reflux (2 h);;
参考文献
Banks, R. E.; Burgess, J. E.; Cheng, W. M.; Haszeldine, R. N.
Journal of the Chemical Society, 1965 , p. 575 - 594
Full Text Show Details
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
Full Text Show Details
Haszeldine, R. N.; Banks, R. E.
Patent: US3317542 , 1967 ;
C.A., 1968 , vol. 68, p. 59442
反应条件
in tert-butyl alcohol
参考文献
Banks, R. E.; Burgess, J. E.; Cheng, W. M.; Haszeldine, R. N.
Journal of the Chemical Society, 1965 , p. 575 - 594
Full Text Show Details
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
Full Text Show Details
Haszeldine, R. N.; Banks, R. E.
Patent: US3317542 , 1967 ;
C.A., 1968 , vol. 68, p. 59442
