[1,3]二氧杂环戊并[4,5-g]异喹啉合成路线 （共 28 条）
反应条件
1: 97.8 percent / 5percent aq. K2CO3 / methanol / 0.25 h / Heating
2: 68.9 percent / Et3N, 4-(dimethylamino)pyridine (DMAP) / CHCl3 / 26 h / Ambient temperature
3: Bu3SnH, AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
反应条件
in ethylene glycol dimethyl ether
120 h; Heating;
参考文献
Grotjahn; Vollhardt
Synthesis, 1993 , # 6 p. 579 - 605
反应条件
sodium hydride
1.) DMF, -10 deg C, 5 min, 2.) a) 0 deg C, 2 h, b) 20 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hung; Mooney; Prager; Ward
Australian Journal of Chemistry, 1981 , vol. 34, # 1 p. 151 - 162
反应条件
2: LiAlH4 / tetrahydrofuran / Heating
View Scheme
参考文献
Brooks, Donald J.; Dowell, David S.; Minter, David E.; Villarreal, Mark C.
Journal of Organic Chemistry, 1984 , vol. 49, p. 130 - 133
参考文献
Pfizer Inc.
Patent: US6248738 B1, 2001 ;
反应条件
1: CH2Cl2 / 7 h
2: 74 percent / NaH / dimethylformamide / 1 h / 20 °C
3: 41 percent / CF3COOH; NaBH3CN / acetic acid / 0.42 h
4: 95 percent / KOH / ethanol
5: 81 percent / 0.17 h / Heating
View Scheme
参考文献
Reimann, Eberhard; Grasberger, Fritz; Polborn, Kurt
Monatshefte fur Chemie, 2003 , vol. 134, # 7 p. 991 - 1014
反应条件
in dichloromethane; water
8 h; Ambient temperature;
参考文献
Chantimakorn, Vilai; Nimgirawath, Surachai
Australian Journal of Chemistry, 1989 , vol. 42, # 1 p. 209 - 213
参考文献
Eisai Co., Ltd.
Patent: EP1300464 A1, 2003 ;
