4-氧四氢噻酚-3-羧酸甲酯合成路线 （共 15 条）
反应条件
1: barium carbonate; methanol; hydroxylamine hydrochloride / Behandeln einer Loesung des erhaltenen Oxims (Oel) in Aether mit Chlorwasserstoff enthaltendem Methanol
2: sodium acetate
View Scheme
参考文献
Baker et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 133,136
参考文献
Evans, Elizabeth H.; Hewson, Alan T.; March, Lorraine A.; Nowell, Ian W.; Wadsworth, Alan H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 137 - 150
反应条件
1: toluene / Heating
2: N-chloro-succinimide / pyridine
3: P2S5 / pyridine / Heating
4: KOH / dioxane; methanol
5: AcOH / xylene / Heating
View Scheme
参考文献
Press,J.B. et al.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 725 - 731
反应条件
1: (i), (ii) N-chloro-succinimide
2: P2S5 / pyridine / Heating
3: KOH / dioxane; methanol
4: AcOH / xylene / Heating
View Scheme
参考文献
Press,J.B. et al.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 725 - 731
反应条件
acetic acid in ethanol
4 h; Heating;
参考文献
Chakrabarti; Fairhurst; Gutteridge; Horsman; Pullar; Smith; Steggles; Tupper; Wright
Journal of medicinal chemistry, 1980 , vol. 23, # 8 p. 884 - 889
