4-氧四氢噻酚-3-羧酸甲酯合成路线 （共 15 条）
反应条件
1: With sodium methylate in tetrahydrofuran T=20°C; 2.08333 h; Reflux; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
LAILA NUTRACEUTICALS
Patent: US2010/68178 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium methylate in methanol 0.666667 h; Heating / reflux;
参考文献
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
Patent: WO2006/97449 A1, 2006 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: 2-mercaptoacetic acid methyl ester With sodium methylate in methanol T=20°C; 3 h; 2: acrylic acid methyl ester in dimethyl sulfoxide T=0 - 20°C; Michael addition; Dieckmann cyclization; 18 h; 3: With hydrogenchloride in water; dimethyl sulfoxide
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94400 A2, 2004 ;
Location in patent: Page 41 ;
WO 2004/094400 A2
反应条件
sodium hydride T=-40°C; 5 h;
参考文献
Liu, Hsing-Jang; Ngooi, Teng Ko
Canadian Journal of Chemistry, 1982 , vol. 60, p. 437 - 439
反应条件
MH2OH*HCl in acetonitrile 1 h; Heating;
参考文献
Barker, John M.; Huddleston, Patrick R.; Wood, Michael L.
Synthetic Communications, 2002 , vol. 32, # 16 p. 2565 - 2568
反应条件
acetic acid in methanol; water T=0°C; 8 h;
参考文献
Leban, Johann; Kralik, Martin; Mies, Jan; Gassen, Michael; Tentschert, Karin; Baumgartner, Roland
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4854 - 4857
参考文献
Woodward; Eastman
Journal of the American Chemical Society, 1946 , vol. 68, p. 2229,2233
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Buchman; Cohen
Journal of the American Chemical Society, 1944 , vol. 66, p. 847
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Karrer; Schmid
Helvetica Chimica Acta, 1944 , vol. 27, p. 124,126
反应条件
toluene-4-sulfonic acid in benzene Heating;
参考文献
Basarab, Gregory S.; Jordan, Douglas B.; Gehret, Troy C.; Schwartz, Rand S.
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4143 - 4154
反应条件
1: sodium carbonate / water / 20 °C / |Darkness
2: water; hydrogenchloride; acetic acid / |Reflux
3: dichlorophenyl phosphine oxide / 135 - 165 °C
View Scheme
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
反应条件
dihydrogen peroxide in methanol
2 h;
参考文献
Banks, Malcolm R.; Barker, John M.; Huddleston, Patrick R.
Journal of Chemical Research, Miniprint, 1984 , # 2 p. 369 - 389
